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juanzijiayou金虫 (小有名气)
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[求助]
阿莫西林的溶解性？ 已有1人参与
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| 阿莫西林的白色粉末，想知道这个药物能溶于哪些有机溶剂？有看到说它的三水酸是微溶于水的，钠盐则易溶于水，不知道有没有哪些常见有机溶剂很好溶的？希望各位指点，不胜感激！ |
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2楼2013-09-26 21:42:27
juanzijiayou
金虫 (小有名气)
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3楼2013-09-27 15:16:09
4楼2013-09-28 11:05:38
5楼2017-04-09 15:09:27
【答案】应助回帖
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Amoxicillin Structural Formula Vector Image Title: Amoxicillin CAS Registry Number: 26787-78-0 CAS Name: (2S,5R,6R)-6-[[(2R)-Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Additional Names: (-)-6-[2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-[D(-)-a-amino-p-hydroxyphenylacetamido]penicillanic acid; a-amino-p-hydroxybenzylpenicillin; 6-(p-hydroxy-a-aminophenylacetamido)penicillanic acid; p-hydroxyampicillin; amoxycillin; AMPC Trademarks: Helvamox (Helvepharm); Pasetocin (Kyowa); Penimox (IBSA); Supramox (Grñenthal); Zamocilline (Inpharzam) Molecular Formula: C16H19N3O5S Molecular Weight: 365.40 Percent Composition: C 52.59%, H 5.24%, N 11.50%, O 21.89%, S 8.78% Literature References: Semi-synthetic antibiotic related to penicillin. Prepn: Nayler, Smith, GB 978178 (1964 to Beecham); eidem, US 3192198 (1965); Long, Nayler, DE 1942693 and GB 1241844 (1970 and 1971 to Beecham), C.A. 72, 90447q (1970). Resolution of isomers: Long et al., J. Chem. Soc. C 1971, 1920. Series of articles on activity, pharmacology, absorption and excretion: Antimicrob. Agents Chemother. 1970, 407-430. Review of antibacterial activity, pharmacokinetics and therapeutic use: R. N. Brogden et al., Drugs 18, 169-184 (1979). Comprehensive description: A. E. Bird, Anal. Profiles Drug Subs. Excip. 23, 1-52 (1994). Derivative Type: Trihydrate CAS Registry Number: 61336-70-7 Manufacturers' Codes: BRL-2333 Trademarks: Agram (Fabre); Alfamox (Teofarma); Amocilline (Inpharzam); Amodex (Bouchara); Amoram (Eastern); Amoxidin (Lagap); Amoxil (GSK); Amoxillat (Novartis); Amoxypen (Grñenthal); Ardine (Antibioticos); Bactox (Innotech); Betamox (Norbrook); Bristamox (BMS); Cuxacillin (TAD); Flemoxine (Yamanouchi); Gramidil (Dexo); Hiconcil (BMS); Larotid (Roche); Ospamox (Novartis); Polymox (BMS); Robamox (Wyeth); Sigamopen (Alpharma); Trimox (BMS); Velamox (GSK); Widecillin (Meiji); Wymox (Wyeth); Zimox (Pfizer) Properties: Off-white crystalline powder. [a]D20 +246° (c = 0.1). uv max (ethanol): 230, 274 nm (e 10850, 1400); (0.1N HCl): 229, 272 nm (e 9500, 1080); (0.1N KOH): 248, 291 (e 2200, 3000). Solubility (mg/ml): water 4.0; methanol 7.5; abs ethanol 3.4. Insol in hexane, benzene, ethyl acetate, acetonitrile. Optical Rotation: [a]D20 +246° (c = 0.1) Absorption maximum: uv max (ethanol): 230, 274 nm (e 10850, 1400); (0.1N HCl): 229, 272 nm (e 9500, 1080); (0.1N KOH): 248, 291 (e 2200, 3000) Derivative Type: Sodium salt CAS Registry Number: 34642-77-8 Trademarks: Clamoxyl (GSK); Ibiamox (IBI) Molecular Formula: C16H18N3NaO5S Molecular Weight: 387.39 Percent Composition: C 49.61%, H 4.68%, N 10.85%, Na 5.93%, O 20.65%, S 8.28% Therap-Cat: Antibacterial. Therap-Cat-Vet: Antibacterial. Keywords: Antibacterial (Antibiotics); ?Lactams; Penicillins. |
6楼2017-04-24 19:52:25
