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Fischer‘s interest in other heterocyclic molecules found in nature led to the first synthesis of caffeine，which is the stimulant in coffee and tea .The purine ring system found in caffeine also comprises the ring system of heterocyclic bases adenine and quanine that are found in nucleic acids. he also developed a general sysnthesis of indole,the heterocyclic ring-containing component in the amino acid trypophan,and the method is known today as the Fischer indole synthesis While Fischer must have taken satisfaction and joy from hin scientific accomplishments, his personal life ended in tragedy. before moving to berlin ,hemarried Agnes Gerlach with whom he had three sons . his wife died at the age of 33 , and two of his sons were killed in World War I. by the end of the war ,Fischer himself suffered from mercury and phenylhydrazine poisoning and advanced intestinal cancer . Depressed by his own poor health , the losses of his wife and two sons , and the socioeconomic conditions of post-war Germany, he committed suicide in 1919 . however , his legacy as one of the great bio-organic chemists in the history of the science lives to this day. |
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