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Carbonic Anhydrase: Its Inhibitors and Activators
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Carbonic Anhydrase: Its Inhibitors and Activators (Taylor & Francis Medicinal Chemistry Series) By Claudiu T. Supuran, Andrea Scozzafava, and Janet Conway Publisher: CRC Number Of Pages: 376 Publication Date: 2004-05-27 Sales Rank: 2508878 ISBN / ASIN: 0415306736 EAN: 9780415306737 Binding: Hardcover Manufacturer: CRC Studio: CRC Average Rating: Total Reviews: ________________________________________ Book Description: Carbonic anhydrases (CAs) are metalloenzymes that regulate important physiological functions in organisms throughout the plant and animal kingdoms. These enzymes are found in numerous forms, and in numerous tissues, and present an attractive target for the design of inhibitors and activators with therapeutic value. CA inhibitor-based drugs have been approved for the treatment of glaucoma, and show promise in the areas of oncology, gastroenterology, neurology, nephrology and dermatology; CA activators may prove useful in treating Alzheimer's disease and memory disorders. Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of internationally recognized experts, this authoritative edition is a leading reference for bioscientists across many disciplines, as well as novices interested in the latest developments in this complex field. An understanding of the mechanisms through which carbonic anhydrases interact with their inhibitors and activators in complex biological environments is essential in developing novel therapeutic agents for the treatment of disease. Table of Contents Chapter 1 Carbonic Anhydrases: Catalytic and Inhibition Mechanisms, Distribution and Physiological Roles .................................................1 Claudiu T. Supuran Chapter 2 Acatalytic CAs: Carbonic Anhydrase-Related Proteins....................25 Isao Nishimori Chapter 3 Multiple Binding Modes Observed in X-Ray Structures of Carbonic Anhydrase Inhibitor Complexes and Other Systems: Consequences for Structure-Based Drug Design.............................45 Jochen Antel, Alexander Weber, Christoph A. Sotriffer and Gerhard Klebe Chapter 4 Development of Sulfonamide Carbonic Anhydrase Inhibitors........67 Claudiu T. Supuran, Angela Casini and Andrea Scozzafava Chapter 5 QSAR Studies of Sulfonamide Carbonic Anhydrase Inhibitors....149 Brian W. Clare and Claudiu T. Supuran Chapter 6 Metal Complexes of Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors.......................183 Joaquín Borrás, Gloria Alzuet, Sacramento Ferrer and Claudiu T. Supuran Chapter 7 Nonsulfonamide Carbonic Anhydrase Inhibitors...........................209 Marc Antoniu Ilies and Mircea Desideriu Banciu Chapter 8 Clinical Applications of Carbonic Anhydrase Inhibitors in Ophthalmology....................243 Francesco Mincione, Luca Menabuoni and Claudiu T. Supuran Chapter 9 Cancer-Related Carbonic Anhydrase Isozymes and Their Inhibition.......................255 Silvia Pastoreková and Jaromír Pastorek Chapter 10 Role of Carbonic Anhydrase and Its Inhibitors in Biological Science Related to Gastroenterology, Neurology and Nephrology......................................................................................283 Seppo Parkkila, Anna-Kaisa Parkkila and Jyrki Kivelä Chapter 11 Carbonic Anhydrase Inhibitors in Dermatology ............................303 Antonio Mastrolorenzo, Giuliano Zuccati, Andrea Scozzafava and Claudiu T. Supuran Chapter 12 Carbonic Anhydrase Activators .......................................................317 http://www.91files.com/?BXU7K7A4XTNUQ1BMB1F7 |
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