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Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery
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Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery (Methods and Principles in Medicinal Chemistry) By Klaus Wanner, Georg Höfner Publisher: Wiley-VCH Number Of Pages: 460 Publication Date: 2007-04-20 ISBN / ASIN: 3527314563 -------------------------------------------------------------------------------- Book Description: This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding. Contents Preface XV A Personal Foreword XVII List of Contributors XIX I Introduction to MS in bioanalysis 1 1 Mass Spectrometry in Bioanalysis – Methods, Principles and Instrumentation 3 Ge´rard Hopfgartner http://www.91files.com/?0H5WCA6A4NM5ZJCSJQO3 |
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