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Drug Delivery: Principles and Applications
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Drug Delivery: Principles and Applications (Wiley Series in Drug Discovery and Development) By Binghe Wang, Teruna J. Siahaan, Richard A. Soltero, Publisher: Wiley-Interscience Number Of Pages: 464 Publication Date: 2005-03-28 ISBN / ASIN: 0471474894 -------------------------------------------------------------------------------- Book Description: An indispensable tool for those working at the front lines of new drug development Written for busy professionals at the forefront of new drug development, Drug Delivery gets readers quickly up to speed on both the principles and latest applications in the increasingly important field of drug delivery. Recent developments in such areas as combinatorial chemistry, proteomics, and genomics have revolutionized researchers' ability to rapidly identify and synthesize new pharmacological compounds. However, delivery-related properties remain a significant reason for clinical trial failures. Bringing together contributions by leading international experts, Drug Delivery covers the entire field in a systematic but concise way. It begins with an in-depth review of key fundamentals, such as physiochemical and biological barriers; drug delivery pathways; metabolism; drug formulation; pharmacokinetic and pharmacodynamic issues; and more. The remainder of the book is devoted to the systematic examination-including overviews, timely examples, and extensive references-of a host of specific subjects, including: * Receptor-mediated drug delivery * Prodrug delivery approaches * Oral protein and peptide drug delivery * Gene therapy and gene delivery * Ultrasound-mediated drug delivery * Polycationic peptides and proteins in drug delivery * Pulmonary drug delivery * Antibody-directed drug delivery * Efflux transporters in drug excretion * Intellectual property issues in drug delivery Preface vii List of Contributors ix 1 Factors That Impact the Developability of Drug Candidates: An Overview 1 Chao Han and Binghe Wang 2 Physiological, Biochemical, and Chemical Barriers to Oral Drug Delivery 15 Anna Maria Calcagno and Teruna J. Siahaan 3 Pathways for Drug Delivery to the Central Nervous System 29 Yan Zhang and Donald W. Miller 4 Physicochemical Properties, Formulation, and Drug Delivery 57 Dewey H. Barich, Mark T. Zell, and Eric J. Munson 5 Targeted Bioavailability: A Fresh Look at Pharmacokinetic and Pharmacodynamic Issues in Drug Delivery 73 William F. Elmquist 6 Presystemic and First-Pass Metabolism 83 W. Griffith Humphreys 7 Cell Culture Models for Drug Transport Studies 103 D. Nedra Karunaratne, Peter S. Silverstein, Veena Vasandani, Amber M. Young, Erik Rytting, Bradley Yops, and Kenneth L. Audus 8 Prodrug Approaches to Drug Delivery 125 Longqin Hu 9 Receptor-Mediated Drug Delivery 167 Christopher P. Leamon and Philip S. Low 10 Oral Protein and Peptide Drug Delivery 189 Rick Soltero 11 Metabolic Activation and Drug Targeting 201 Xiangming Guan 12 Ultrasound-Mediated Drug Delivery 245 Ka-yun Ng and Terry O. Matsunaga 13 Polycationic Peptides and Proteins in Drug Delivery: Focus on Nonclassical Transport 279 Lisa A. Kueltzo and C. Russell Middaugh 14 Gene Therapy and Gene Delivery 305 Naoki Kobayashi, Makiya Nishikawa, and Yoshinobu Takakura 15 Parenteral Formulation for Peptides, Proteins, and Monoclonal Antibodies Drugs: A Commercial Development Overview 321 John A. Bontempo 16 Pulmonary Drug Delivery: Pharmaceutical Chemistry and Aerosol Technology 341 Anthony J. Hickey 17 Antibody-Directed Drug Delivery 363 Herve´ Le Calvez, John Mountzouris, Kosi Gramatikoff, and Fang Fang 18 Efflux Transporters in Drug Excretion 381 Shuzhong Zhang and Marilyn E. Morris 19 Liposomes as Drug Delivery Vehicles 411 Guijun Wang 20 Regulatory and Intellectual Property Issues in Drug Delivery Research 435 Shihong Nicolaou Index 443 http://www.91files.com/?14R07QUMAQ76ZKP8ZTHC |
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