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Functional Informatics in Drug Discovery
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Functional Informatics in Drug Discovery By Sergey Ilyin Publisher: CRC Number Of Pages: 160 Publication Date: 2007-08-21 Sales Rank: 974496 ISBN / ASIN: 1574444662 EAN: 9781574444667 Binding: Hardcover Manufacturer: CRC Studio: CRC Average Rating: Total Reviews: -------------------------------------------------------------------------------- Book Description: Integrating various technologies with informational systems provides vast improvements to the overall research and development that occur in the biopharmaceutical industry. One of the first books to explore this area, Functional Informatics in Drug Discovery examines all aspects of technology integration and information flow in a biopharmaceutical enterprise and outlines the specific technologies used at various stages of drug development. With contributions from leaders in academia, information technology, and the pharmaceutical industry, each chapter illustrates how a particular area of biological science can benefit from the tools of informatics. The book first looks at intelligent automation, neurally based computational tools, and pharmacodynamic (PD) biomarkers. It then reviews a variety of novel technologies and approaches presently used in drug discovery at Johnson & Johnson. The text also describes how informatics can advance antibody technology and drug development for oncology. After focusing on forward genetic and reverse genetic strategies to identify relevant target genes for drug discovery, the book explains proteomic expression profiling and explores the application of laser microdissection in transcriptomics. Taking a systematic approach, this volume examines the impact of informatics tools on various areas in biopharmaceuticals by presenting in-depth analyses of emerging trends and future opportunities. Preface......................................................................................................................vii Editor.........................................................................................................................ix Contributors ..............................................................................................................xi Chapter 1 Intelligent Automation .........................................................................1 James M. Dixon Chapter 2 Neurally Inspired Algorithms as Computational Tools.....................13 Mark Flynn and Garrett T. Kenyon Chapter 3 Using Pharmacodynamic Biomarkers to Accelerate Early Clinical Drug Development ...........41 Ole Vesterqvist Chapter 4 Opportunities in CNS Drug Discovery and Development................55 Albert Pinhasov, Anil H. Vaidya, Hong Xin, Daniel Horowitz, Daniel Rosenthal, Douglas E. Brenneman, Ewa Malatynska, Sergey E. Ilyin, and Carlos R. Plata-Salamán Chapter 5 Clinical Success of Antibody Therapeutics in Oncology .................65 Bernard J. Scallon, Linda A. Snyder, G. Mark Anderson, Qiming Chen, Li Yan, and Marian T. Nakada Chapter 6 Relating Target Sequence to Biological Function.............................91 Greg M. Arndt Chapter 7 Use of Protein Microarrays for Molecular Network Analysis and Signal-Pathway Profiling ......115 Katherine R. Calvo, Lance A. Liotta, and Emanuel F. Petricoin Chapter 8 Laser-Microdissection-Based Transcriptomics Using Microarrays ....131 Fredrik Kamme, Bernd Meurers, Jessica Zhu, Da-Thao Tran, Jingxue Yu, Changlu Liu, Andrew Carmen, and Bingren Hu Index.................................................141 http://www.91files.com/?HTE7NTLSQ2MPT93IOWU1 |
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