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The use of biocatalysts (enzymes and engineered whole cells) in the manufacture of chemicals can offer major advantages in terms of economic and environmental sustainability. Compared to traditional chemical catalysts, enzymes generally have exquisite levels of chemo-, regio-, and enantioselectivity, in addition to high rates of turnover. Such properties are of great benefit to the pharmaceutical and fine chemical industry, and indeed biocatalysis is now finding broader application in other sectors, including agrochemicals, personal healthcare products, polmers and biofuels. The research interests of our group encompass a broad range of biocatalysts including oxidases, P450 monooxygenases, ammonia lyases, racemases, carboxylic reductases, transaminases and lipases. Particular emphasis has been placed on using directed evolution technologies to develop enzymes that have enhanced properties including broader substrate specificity, increased enantioselectivity and also enhanced stability when used on larger scale for preparative applications. We are particularly interested in the development of multienzyme and also chemo-enzymatic processes in which two or more bio-/chemo-catalysts are combined. In this context we are developing new tools and technologies for Synthetic Biology. Our work in this area has recently begun to yield major benefits, e.g. in the application of monoamine oxidases for the enantioselective desymmetrisation of a key building block for the synthesis of telaprevir (treatment for hepatitis C). |
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