| 查看: 679 | 回复: 3 | |||
325865959铜虫 (初入文坛)
|
[求助]
请问有没有模拟酶分子酸碱耐受性的算法，软件，或者综述？
|
|
见过模拟蛋白质热稳定性的算法，但是有没有模拟酶分子酸碱耐受性的算法呢？都是什么原理呀？一般工业酶改造需要用到提高酸碱耐受范围，是随机突变呢还是有理性设计的方法指导？ [ Last edited by 325865959 on 2013-5-24 at 11:22 ] |
回复此楼» 猜你喜欢
材料学求调剂
已经有6人回复
-
303求调剂
已经有5人回复
-
一志愿武理085500机械专业总分300求调剂
已经有7人回复
-
考研调剂
已经有4人回复
-
281求调剂
已经有4人回复
-
0805 316求调剂
已经有6人回复
-
085601求调剂总分293英一数二
已经有3人回复
-
08工学调剂
已经有17人回复
-
340求调剂
已经有4人回复
-
311求调剂
已经有3人回复
» 本主题相关商家推荐: (我也要在这里推广)
325865959
铜虫 (初入文坛)
- 应助: 0 (幼儿园)
- 金币: 145.3
- 帖子: 41
- 在线: 24.7小时
- 虫号: 2344181
- 注册: 2013-03-13
- 性别: MM
- 专业: 微生物生理与生物化学
| pKD software: "The pKa values inproteins governthe pH-dependence of protein stability and enzymatic activity. A large number of mutagenesis experiments have been carried out in the last three decades to re-engineer the pH-activity and pH-stability profile of enzymes and proteins. We have developed the pKD webserver (http://polymerase.ucd.ie/pKa_Design), which predicts sets of point mutations that will change the pKa values of a set of target residues in a given direction, thus allowing for targeted re-design of the pH-dependent characteristics of proteins." |
2楼2013-05-27 12:50:53
325865959
铜虫 (初入文坛)
- 应助: 0 (幼儿园)
- 金币: 145.3
- 帖子: 41
- 在线: 24.7小时
- 虫号: 2344181
- 注册: 2013-03-13
- 性别: MM
- 专业: 微生物生理与生物化学
| PROPKA software: "The PROPKA Graphical User Interface (GUI) is a new tool for studying the pH-dependent properties of proteins such as charge and tabilization energy. It facilitates a quantitative analysis of pKa values of ionizable residues together with their structural determinants by providing a direct link between the pKa data, predicted by the PROPKA calculations, and the structure via the Visual Molecular Dynamics (VMD) program." |
3楼2013-05-27 12:55:56
1054950560
金虫 (正式写手)
- 应助: 1 (幼儿园)
- 金币: 1338.7
- 散金: 25
- 红花: 7
- 帖子: 327
- 在线: 138.2小时
- 虫号: 1658658
- 注册: 2012-03-02
- 性别: GG
- 专业: 药物化学
4楼2013-05-27 16:31:18
