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偏理论些！！！ 希望各位喜欢！！！ Introduction ............................................................... 5 DNA.................................................................. 6 Genes............................................................................... 7 Chromosomes ......................................................................... 8 Mapping and Sequencing the Human Genome ............................ 10 Mapping Strategies ............................................................... 11 Genetic Linkage Maps ............................................. 11 Physical Maps......................................................................... 13 Low-Resolution Physical Mapping.................................................. 14 Chromosomal map ...................................................................... 14 cDNA map ............................................................................. 14 High-Resolution Physical Mapping .................................................... 14 Macrorestriction maps: Top-down mapping .................................. 16 Contig maps: Bottom-up mapping.............................................. 17 Sequencing Technologies ........................................................ 18 Current Sequencing Technologies ............................................. 23 Sequencing Technologies Under Development .............................. 24 Partial Sequencing to Facilitate Mapping, Gene Identification .................. 24 End Games: Completing Maps and Sequences; Finding Specific Genes ...... 25 Model Organism Research................................................................... 27 Informatics: Data Collection and Interpretation ..................................... 27 Collecting and Storing Data .................................................. 27 Interpreting Data .......................................................................... 28 Mapping Databases .......................................................................... 29 Sequence Databases ................................................................... 29 Nucleic Acids (DNA and RNA)......................................................... 29 Proteins ....................................................................... 30 Impact of the Human Genome Project ......................................... 30 Glossary... .............................................................................. 32 |
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