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[资源] 分享Chemical review上关于核酸电化学的文章Electrochemistry of Nucleic Acids

题目：Electrochemistry of Nucleic Acids
信息：Palecek E, Bartosik M. Electrochemistry of Nucleic Acids[J]. CHEMICAL REVIEWS, 2012,112(6):3427-3481.
ACS出版物链接：http://pubs.acs.org/doi/abs/10.1021/cr200303p
目录：
1. Introduction and Scope
1.1. Electrochemistry of Nucleic Acids is a Booming Field
1.2. Progress in Genomics Influences Electrochemistry of Nucleic Acids
1.3. Electrochemical DNA Hybridization Sensors
2. Early Studies and the Lag Period
2.1. From History to Present Time
3. Reduction, Oxidation, and Adsorption of Nucleic Acids at Electrodes
3.1. Electroactivity of Nucleic Acids Components
3.1.1. Reduction Signals
3.1.2. Oxidation Signals
3.1.3. Stripping Techniques
3.1.4. Unusual NA Components
3.2. Electroactivity of Nucleic Acids
3.2.1. Reduction Signals
3.2.2. Oxidation Signals
3.2.3. Changes in DNA Structure
3.2.4. Adsorptive Stripping Techniques
3.2.5. DNA-Modified Electrodes
3.2.6. Solid Amalgam Electrodes
3.3. Adsorption of Nucleic Acids and Their Components at Electrodes
3.3.1. Adsorption at Mercury Electrodes
3.3.2. Adsorption at Carbon Electrodes
4. Potential-Driven Changes in Conformation of Surface-Attached DNA
4.1. Introduction
4.2. NA Molecules Noncovalently Bound to Negatively Charged Surfaces
4.2.1. Long DNA and RNA Molecules
4.2.2. Biosynthetic Double-Stranded Polynucleotides
4.2.3. Carbon Electrodes
4.2.4. Closed Circular Duplex DNA Molecules
4.2.5. DNA Surface Unwinding and Detection of DNA Damage
4.2.6. Effect of Base Ionization
4.2.7. Tentative Scheme of the DNA Surface Denaturation
4.2.8. Other Surfaces and Detection Methods
4.2.9. Electric Field Effects as Detected by Fluorescence
4.3. Oligonucleotides Covalently Bound to Electrode Surfaces
4.3.1. Electrochemical Melting and SERS Monitoring
4.3.2. Electric Field Effects
4.4. DNA Duplex Structure at Electrode Surfaces
4.5. Concluding Remarks
5. Advances in the Development of DNA Hybridization Sensors
5.1. Single- and Double-Surface Techniques
5.2. Label-Free and Label-Based DNA Sensing
5.2.1. Label-Free Techniques
5.2.2. Electrochemical Impedance Spectroscopy
5.2.3. DNA Labeling and Label-Based Techniques
5.3. Nanotechnology in DNA Sensors
5.3.1. Nanoelectrodes
5.3.2. Nanoparticles
5.3.3. Carbon Nanotubes
5.4. Electronically Conducting Polymers
5.5. Electrochemical Molecular Beacons
5.6. DNA Charge Transfer
5.7. Detection of Single-Base Mismatches in DNA
5.8. Detection of DNA Methylation
5.9. Double-Stranded Target DNAs
5.9.1. Triplex Structures
5.9.2. Sequence-Specific DNA–Protein Binding and Detection of Point Mutations
5.9.3. Detection of Point Mutation (Single-Base Mismatch) in dsDNA by Means of MutS Protein
5.9.4. Sequence-Specific Binding of p53 Protein to dsDNA
5.10. Concluding Remarks
6. Analysis of Biologically-Relevant Samples
6.1. PCR-Amplified DNAs
6.1.1. End-Point Detection of PCR Amplicons
6.1.2. Trinucleotide Repeat Expansion
6.1.3. Real-Time PCR Amplicons Detection
6.2. Combination of Biochemical and Electrochemical Approaches
6.2.1. Genomic DNA
6.2.2. Sequences Inserted Into Plasmids
6.3. Ribonucleic Acids
6.3.1. Analysis of Uropathogen rRNA Sequences
6.3.2. Improved Shielding of Electrode Surfaces by Binary and Ternary SAMs
6.3.3. mRNA
6.3.4. MicroRNAs
7. Detection of DNA Damage
7.1. Strand Breaks in DNA
7.2. Damage to Bases in DNA
8. Biodevices: DNA Microarrays and Lab-on-a-Chip
9. Summary and Conclusion