| 查看: 4222 | 回复: 93 | ||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | ||
[资源]
《细胞》【Cell】2013年04月25日全文PDF版本
|
||
|
《细胞》【Cell】2013年04月25日全文PDF版本 Brain Origami Master PAGE 535 During evolution, the mammalian brain has undergone enormous expansion, with correspondingchanges in gyrification (folding). Stahl et al. show that levels of a DNA-associatedprotein, Trnp1, determine whether the cortex expands tangentially or radially and alsoregulate its gyrification. Trnp1 levels in the developing human brain correlate with regionallevels of folding. TNF Excess: TB or Not TB PAGE 521 Tumor necrosis factor has been shown to be protective in tuberculosis. Roca and Ramakrishnan find that excess TNF levels, however, induce mitochondrial ROS and leadto macrophage necroptosis. This results in the lysis of infected macrophages and releaseof mycobacteria into the extracellular milieu, where they are able to grow unfettered. Pharmacological modulation of necroptosismay help to preserve macrophage microbicidal activity and confer tuberculosis resistance to individuals with excess TNF. Cell Sorting Nixes Noise in Development PAGE 550 Patterning and morphogenesis often occur concurrently in development. Using in toto imaging in the zebrafish neural tube, Xionget al. show that cell movements during morphogenesis create ‘‘noise’’ in the positional information encoded by the Sonic hedgehogmorphogen gradient. As a result, cells of different fates are specified in mixed and overlapping patterns. Fate-specific cell movementshen create sharp boundaries between cell-type domains. Thus, morphogenetic cell movements can both limit and correctpositional information. RNA Editor Meets RNA Silencer PAGE 575 ADAR1 is a homodimeric RNA-editing enzyme that converts adenosine to inosine in dsRNA. Ota et al. now show that ADAR1 alsoplays a completely different role as an RNAi regulator. When an ADAR1 monomer forms a complex with Dicer, it acts as an RNAsilencer by promoting miRNA processing, RISC loading, and RNAi efficacy. miRNA expression is globally suppressed in mouseembryos lacking ADAR1, altering expression of miRNA targets and contributing to embryonic lethality.Vitamins Smack Down SMAD in Liver Injury PAGE 601 Ding et al. show that vitamin D receptor (VDR) signaling inhibits liver fibrosis (scarring) by antagonizing the action of SMAD transcriptional regulators in hepatic stellate cells. SMADs are activated by liver injury and, in the absence of VDR ligands, activate profibroticgenes. However, they also enable their own repression by making the chromatin around their target sites more accessible to VDR thatwill bind and inhibit SMAD activity in the presence of VDR ligands. Tanking the Proteasome PAGE 614 Selective protein degradation by the ubiquitin-proteasome system plays a vital role in cellular homeostasis. Defects in this process are associated with various human diseases,and the proteasome is a validated drug target in cancer therapy. Cho-Park and Stellershow that Tankyrase-mediated ADP-ribosylation of PI31 activates proteasomes bypromoting 26S proteasome assembly and that this process can be blocked withTankyrase-inhibitors. These results reveal a mechanism of proteasome regulation thatcan be targeted with existing small-molecule inhibitors.[ 来自科研家族 生物医药家族 ] |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : Cell2013-4-25.pdf
2013-04-27 09:38:51, 34.46 M
» 猜你喜欢
湖北师范大学招调剂啦
已经有9人回复
-
邵阳学院食品与化学工程学院硕士调剂
已经有0人回复
-
化学工程及工业化学论文润色/翻译怎么收费?
已经有148人回复
-
天津商业大学 生物与医药课题组招生
已经有0人回复
-
生物化工学硕招收调剂
已经有0人回复
-
广东石油化工学院2026年硕士研究生需要多名生物，制药工程，食品专业的调剂生
已经有0人回复
-
化工申博
已经有3人回复
-
申博自荐
已经有3人回复
-
广西民族大学化学化工学院化学工程与技术学硕，材料化工专硕调剂名额充足！
已经有0人回复
» 本主题相关商家推荐: (我也要在这里推广)
好的，真心受教了！！ 67楼2013-05-31 07:42:54
非常感谢，谢谢分享，顶！ 5楼2013-04-27 11:34:47
简单回复
經天2楼
2013-04-27 10:19
回复
五星好评 顶一下，感谢分享！
wjw31883楼
2013-04-27 11:23
回复
五星好评 顶一下，感谢分享！
yy0015194楼
2013-04-27 11:33
回复
五星好评 顶一下，感谢分享！
2013-04-27 11:55
回复
五星好评 顶一下，感谢分享！
2013-04-27 17:19
回复
五星好评 顶一下，感谢分享！
dake20139楼
2013-04-27 18:19
回复
五星好评 顶一下，感谢分享！
tjw0210楼
2013-04-27 20:37
回复
五星好评 顶一下，感谢分享！
西安事变11楼
2013-04-27 21:07
回复
五星好评 顶一下，感谢分享！
whcailian12楼
2013-04-28 06:48
回复
五星好评 顶一下，感谢分享！
dingkui13楼
2013-04-28 06:58
回复
五星好评 顶一下，感谢分享！
nicknelson14楼
2013-04-28 13:23
回复
五星好评 顶一下，感谢分享！
20