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Working list of challenging questions:

1. What are the rules that govern phase separation (i.e. stripes)? What are the rules that govern self-organization (i.e. hierarchical assembly)?

2. How does one describe materials whose electrons are neither perfectly localized nor fully itinerant (i.e. correlated electron systems)?

3. Is there a universal description of quantum transport, including spin transport, ballistic transport, molecular transport, Kondo...?

4. Can one predict the structure and properties of matter from a knowledge of the atomic constituents alone?

5. Is it possible to develop multi-scale methods (both in time and space) to predict the properties of matter?

6. How does one address information with light?

7. What are the ramifications of quantum entanglement and coherency in computation?

8. What is the theory of high-Tc superconductivity? What interactions can successfully pair electrons?

9. Can we integrate materials whose properties tend to be mutually exclusive, such as "ferromagnetic and superconducting", "photonic and semiconducting" and "bio and inorganic"?

10. Can one find nearly 100% spin polarized electron sources and retain interfacial control? Can one create a spin transistor with gain to enable spintronic applications? Can one find magnetic semiconductors that operate well above room temperature?
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