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[求教]有人对Sirolimus有所了解的吗
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| 求教这种药品的物化性质，价格，及哪里有的销售（实验用）。3X |
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3楼2007-09-22 15:25:49
★
可乐=枫(金币+1,VIP+0):谢谢应助。
可乐=枫(金币+1,VIP+0):谢谢应助。
| A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties. |
2楼2007-09-22 15:25:31
★ ★
可乐=枫(金币+2,VIP+0):谢谢应助。
可乐=枫(金币+2,VIP+0):谢谢应助。
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The chemical name of sirolimus (also known as rapamycin) is (3S,6R ,7E,9R ,10R,12R ,14S,15E ,17E,19E ,21S,23S ,26R,27R ,34aS)- 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[(1R)-2- [(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26- hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4] oxaazacyclohentriacontine-1,5,11,28,29 (4H,6H ,31H)-pentone. Its molecular formula is C51H79NO13 and its molecular weight is 914.2. Sirolimus is a white to off-white powder and is insoluble in water, but freely soluble in benzyl alcohol, chloroform, acetone, and acetonitrile. Rapamune® is available for administration as an oral solution containing 1 mg/mL sirolimus. Rapamune is also available as a white, triangular-shaped tablet containing 1-mg sirolimus, and as a yellow to beige triangular-shaped tablet containing 2-mg sirolimus. The inactive ingredients in Rapamune® Oral Solution are Phosal 50 PG® (phosphatidylcholine, propylene glycol, mono- and di-glycerides, ethanol, soy fatty acids, and ascorbyl palmitate) and polysorbate 80. Rapamune Oral Solution contains 1.5% - 2.5% ethanol. 1、西罗莫司，纯度达到98。公司：上海同田生物技术有限公司 地 址：上海张江高科技园区爱迪生路326号 [浦东新区/上海] 联系电话：021-51320588 联 系 人：黄莺 (小姐) 2、公 司： 7chemicals 联 系 人： Mr. OHRI RAKESH Female 电 话： 91-79-26732998 91-98-25407577 传 真： 91-79-26732998 Email： shivam7@icenet.co.in 港口： india 产品等级： 医药级 99% 供货状态： 正常生产 质量认证： GMP;COS;FDA; 质量标准： usp26 |
4楼2007-09-22 21:08:54
