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yin198716

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Many processes involved in tumour angiogenesis are mirrored during embryonic vascular development. In past decade, the Notch pathway has been shown to play a key role in vascular development .Recently, several studies have shown that DLL4/Notch signalling plays an important role in tumour growth by decreasing angiogenesis but improving vessel structure and function. Interruption of DLL4/Notch signalling increased non-productive angiogenesis but dramatically inhibited the growth of either VEGF-sensitive or VEGF-resistant tumours.
Oncology
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zhaolf

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胖虎爱唱歌

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爱与雨下: 金币+1 2013-04-16 19:07:10
sltmac: 金币+15, 翻译EPI+1, 欢迎常来 2013-05-25 20:04:11
参与到肿瘤血管再生的许多过程都在胚胎血管形成中有所映射。在过去十年,Notch通路已被证明在血管发育中起着关键作用。最近,好几个研究指出,DLL4/Notch信号传输在肿瘤生长中通过减少血管再生并提升血管结构和功能而起着重要作用。阻断DLL4/Notch信号传输增加了无效用血管的再生,但在很大程度上抑制了VEGF敏感或VEGF抗性肿瘤的生长。
我是胖虎,我是孩子王!
2楼2013-04-16 01:49:55
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