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| The phase III clinical trials have shown that blockade of the VEGF pathway inhibits tumour progression and prolongs patient survival in several major cancers. However, a number of tumours did not respond or responded in an early stage but became resistance in a late stage to VEGF inhibition in preclinical mouse models. In addition, anti-VEGF therapy alone appears to be ineffective in some clinical trials. |
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2楼2013-04-15 17:29:43