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| The maintenance, growth and metastasis of solid tumours requires angiogenesis, a complex process involving matrix breakdown, endothelial sprouting, proliferation, migration, differentiation, and recruitment of pericytes/smooth muscle cells. Tumour angiogenesis is triggered by a variety of pro-angiogenic molecules, largely produced by tumour and stromal cells and regulated by many angiogenic pathways. |
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2楼2013-04-15 17:46:21
