| 查看: 252 | 回复: 0 | ||
yin198716新虫 (正式写手)
|
[求助]
求助翻译
|
|
Lateral Inhibition Selects the Tip Cell The specification of ECs into tip and stalk cells is controlled by the Notch pathway . Analysis of Notch signaling revealed high Notch activity in stalk cells but low levels of Notch signaling in tip cells. Conversely, tip cells express higher levels of the Notch ligand DLL4. During development or in tumors, blockade of Notch or DLL4 increases filopodia and sprouting as a consequence of excessive tip cell formation. Although ECs express several Notch receptors, Notch1 is critical for suppressing tip cell behavior in stalk cells. The hypersprouting phenotype and excessive number of tip cells following Notch inhibition indicate that the tip cell phenotype is the default endothelial response to proangiogenic signals. In contrast to DLL4, the Notch ligand JAGGED1 (JAG1) is expressed primarily by stalk cells. However, JAG1 poorly activates Notch1, as modification of Notch by FRINGE glycosyltransferases favors activation by DLL4 . Given that some DLL4 protein is detectable in stalk cells, JAG1 helps to maintain differential Notch activity by antagonizing DLL4 that signals back to tip cells. |
回复此楼» 猜你喜欢
售SCI-T0P文章，我:8O.5.5.1.O.54,科目齐全,可+急
已经有6人回复
-
售一区SCI文章T0P，我:8O.551.O54,科目全,可十急
已经有9人回复
-
售SCI-T0P文章，我:8O.5.5.1.O.54,科目齐全,可+急
已经有3人回复
-
考博求助
已经有3人回复
-
售SCI一区文章，我:8.O.551.O.5.4,科目全,可伽急
已经有5人回复
-
售SCI一区T0P文章，我:8.O.55.1.O.5.4,科目全,可+急
已经有4人回复
-
售SCI一区T0P文章，我:8.O.55.1.O.5.4,科目全,可+急
已经有5人回复
-
售SCI-T0P文章，我:8O.5.5.1.O.54,科目齐全,可+急
已经有9人回复
-
售一区SCI文章T0P，我:8O.551.O54,科目全,可十急
已经有9人回复
-
售SCI一区T0P文章，我:8.O.55.1.O.5.4,科目全,可+急
已经有10人回复
