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| Contrary to 3-MCPD, no health-based guidance values have been established for glycidol due to the presumed genotoxic mode of action of its carcinogenicity. The release of glycidol by gastrointestinal lipases in a fashion similar to MCPD esters can also be assumed. Occurrence data available to date are insufficient to estimate what degree of exposure (dietary intake) would be needed to provide a dose, estimated from animal studies, as likely to cause cancer. |
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3楼2013-04-29 20:54:13
【答案】应助回帖
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许卫萍: 金币+5, 翻译EPI+1, ★★★★★最佳答案 2013-05-02 19:53:38
许卫萍: 金币+5, 翻译EPI+1, ★★★★★最佳答案 2013-05-02 19:53:38
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Contrary to 3-MCPD, no health-based guidance values have been established for glycidol due to the presumed genotoxic mode of action of its carcinogenicity. The release of glycidol by gastrointestinal lipases in a fashion similar to MCPD esters can also be assumed. Occurrence data available to date are insufficient to estimate what degree of exposure (dietary intake) would be needed to provide a dose, estimated from animal studies, as likely to cause cancer. 翻译： 与3-MCPD相反，由于其致癌基因的作用方式还是个猜想，缩水甘油还没有确定健康指导值。 也可以假设胃肠道脂肪酶是以一种类似于MCPD酯的方式释放缩水甘油的。 至今可获得的重复数据还不足以估计需要什么样的接触程度（饮食摄入量）来作为一次的剂量，一次的剂量是由动物实验估计出来的，并且这个剂量可能会导致癌症。 |
2楼2013-04-07 20:59:19