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| Angiogenic vessels mature upon the recruitment of pericytes. To understand if DLL4played a role in vessel maturation in human cancer, serial sections were immunostained for CD34 and a -SMA, and an assessment was made of vessel maturation within the DLL4hotspot areas. This is the first time that vessel maturity has been assessed in bladder cancer.a-SMA expression was found on nearly 70% of normal vessels and 85% of tumor vessels studied. The vessels that lacked a -SMA expression were most often microvascular in nature. |
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2楼2013-04-10 09:08:30