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XXX's Statement of Purpose
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Statement of Purpose As an intern in the fermentation department of Huabei Pharmaceuticals Company at Shijiazhuang, China in the summer of 1995, I was impressed by how the pennicillium could produce antibiotic penicillin and therefore, I wanted to learn more about the "cell factory," which is mighty, renewable and environmentally benign. During my undergraduate study at Tianjin University, China, I focused my efforts on the fundamentals and methodologies of industrial chemistry and chemical engineering, especially in analysis as well as synthesis of chemical processes using mathematics and computers. Also, I studied a minor in Biochemical Engineering to enhance my understanding on how to most effectively use the remarkable microbes in finding novel and efficient biological alternatives to old chemical engineering problems, when I came back from Huabei Pharmaceuticals Company. The independent and productive research in immobilized Aspergillus Oryzae cells convinced me to seriously consider biochemical engineering as my career goal. Inspired by seminars in applied and environmental microbiology, biotechnology and bioengineering, I was compelled to further my academic adventures in biochemical engineering. My graduate thesis research focused on the batch fermentation of beta-mannanase and manno-oligosaccharides preparation in the laboratory and pilot plant scale, collaborating with Professor Wenbo Yang from Nankai University and the Bohai Chemical Industrial Group. Taking part in this project from conception to market, I concentrated my efforts on the design, control and scale-up of the fermentor and bioprocessing from the industrial perspective. I designed a set of tailor-made impellers, which was applicable and efficient for the distinctive rheology of the fermentation media with 3.0% konjac powder. I am proud of the kinetic model I set up to simulate and predict beta-mannanase batch fermentation. By means of Genetic Algorithms, the simulation results gave me valuable insight to further explore and exploit the potentials from Bacillus licheniforms NK-27. Through collaborating with people coming from academia and industry, my teamwork ability and the efficiency in real problem solving with critical thinking was greatly enhanced. But I also found that I needed advanced training in upstream bioproccssing, such as isolation, selection and bioengineering bacteria with industrial and/or environment importance to tackle big problems by recombinant DNA technology. Upon earning my Master's degree last year, I went to the Division of Extremophiles and Extremozmes Biotechnology, Institute of Microbiology, Chinese Academy of Sciences and started working on two national key projects. By extending the chemical engineering paradigm of transport, kinetics and modeling to microbiology systems, I successfully employed the engineering concepts and approaches of integration, quantitafion and relevance in the optimization and scale-up of Alginate lyase fermentation by Alkaliphilic Bacillus N19-2. The fermentation enzyme activity increased 5-fold compared with it under initial conditions and the enzyme activity in a 2L fermentor kept as high as, and even higher than, the one in the shaken flask. Also, I learned a lot of experimental skills in molecular cellular biology by participating in cu~ing-edge research in the physiology and enzymology of extreme thermophiles and helping younger graduate students with my boundless energy. Through reading scholarly books and up-to-date journals, running scientific experiments, analyzing data, writing research papers, participating in making academic decisions, my ability to innovate and conduct scientific research has improved significantly. I have published an original paper, co-authored two book chapters and applied for the patent (refer to my Resume) within two years. With my prior enthusiasm and strong commitment to research, multifold research experience and interdisciplinary background in chemistry, bio/chemical engineering and microbiology, I am confident that I have prepared myself well for my upcoming PhD study and research in NC State University. I am very much attracted to your graduate program because: 1) Biochemical Engineering and Technology with emphasis in metabolic analysis and molecular characterization is highlighted in your Chemical Engineering graduate program, which is very compatible with my background and research interest. I can get started as soon as possible on my career path while I am working on my degree. 2) Rarely does any other graduate program so stress creativity, leadership and excellence, which fit my innovative and ambitious nature, and career goal extremely well. 3) Pursuing the PhD in such a large, diverse institution as NC State University would offer me valuable opportunities to do collaboration work and improve my communication skills, which suits my multidisciplinary and diverse orientation well. 4) The concentration of industrial and R&D opportunities in the Research Triangle Park could provide me opportunities for summer internship, co-op position or collaboration project and therefore, put what I learn in the classroom to practical use in the workplace immediately. If admitted, I would like to concentrate my PhD studies in the areas of Biochemical and Process Engineering, Hyperthermophiles Biotechnology and Enzyme Characterization, Metabolic and Protein Engineering, Bioseparations, and Environmental Biotechnology. The common thread through my diverse research interests is to quantitatively re-understand and re-construct chemical processing and production via inspirations from the analogs of chemical industrial and engineering practices with biological systems. A cell could be simple, but it has a huge variety of biochemical talents. By manipulating and controlling the cell itself, as well as the environment in which it functions with my unlimited curiosity and innovation, I could be rewarded with discoveries of new products and processes, even breakthroughs, in these promising areas. Since Biochemical Engineering research in China is still in its initial stage, I plan to lead my own work team at my own "cell factory" research center later and undoubtedly, contribute to the emerging bioeconomy boom in the new century. [ Last edited by googleuc on 2007-9-6 at 11:09 ] |
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Statement of Purpose I should hate to be confined within four walls all day. Luckily my motherland China possesses a bonanza of exotic sites, which instantly cure this illness bordering on claustrophobia. I have marveled at the magnitude of the Inner Mongolia plateau, admired the sunrise on the top of Mt Emei, was entranced by the marvelous Guilin scenery; and traveled alone along the Yangtze River. So it comes as no surprise that I would get hooked on geography and study in the department of Urban and Environmental Sciences, formerly the department of geography, where I found my Mecca and began to build my sailing ship to explore this arena full of amazement and curiosity. It is impossible to navigate without an adequate supply. Thanks to Peking University's rich resources, I have laid a broad and solid base in natural and social sciences, especially in mathematics, biology, chemistry, and computer. For example, when I took Environmental Biology I read intensively four references: Genetics and Biology: Life and Environment, Genetics, Vertebrate zoology and Invertebrate zoology. Wide scope is one of the sources of my confidence. I also have advanced research skills, which enable me to handle water issues at various levels. I can utilize spectrophotometry, chromatography and polography to analyze the water pollutants. Meanwhile I can monitor a large lake with the aid of GIS and RS. Then I tentatively began my virgin voyage. Since I took part in The Water Usage of China international program in 1998, I have been involved in a number of national and international projects. I was the only undergraduate in the research group of Endangered Waterbirds Conservation and Their Habitat Management in Liaohe Delta Wetland. This year I worked as Research Assistant with Professor Jingyun Fang, a famous environmentalist in China. The research subjects in which I participated include bioremediation of wetlands, monitoring of the eutrophication of East Lake, and biodiversity along altitudinal gradients. Currently I am working in an international project - Changes in Habitats and Population Dynamics for Wetland Birds in Dongting Lake. Besides rich hands-on experience, the broad range of the topics and the variety of jobs I have taken provided me with ample opportunities to have insight into many aspects of geography, especially with environmental foci. Not long ago I independently proposed a project: The Economic Loss of the Destruction to Beijing's Historic Buildings Caused by Air Pollution, and it has won the sponsership from our university. To a navigator, a big problem is to find his destination on the broad sea. Fortunately through these projects I have found mine among the numerous areas of geography - to be a specialist in biogeography. As we ascended Mt Changbai to survey the biodiversity there, the vegetation changed gradually from temperate forest to coniferous forest to the tundra at 2691 m above sea level. We seemed to have made a journey from temperate zone to the Arctic! Further analysis revealed that there coexist both Arctic components and tropical components. How have they migrated into the same place? The most common answer is the invasion and retreat of the prehistorical glaciers. But when did they happen? Which one came earlier? How could the tropical component stand the cold when the glacier invaded or vice versa? Another riddle is that Betula ermanii jumps from 2000m to 1500m on Mt Changbai, showing different ecotypes. Such questions regarding "Where and Why" drive me to find the answers with an ecological and evolutionary approach. What's more, study of the distribution of biological material over the earth's surface and the influencing factors logically provides a starting point for our understanding of the role of man in relation to the ecological context. Yet, on the way to my destination await many obstacles. For example, to get a clue out of tons of seemingly unrelated geographic data is as difficult as to look for a needle in a haystack. During the program of Liaohe Delta, I was initially at a loss, but this awkwardness soon changed into excitement after my advisor showed me the compass of GIS. With its aid, we successfully predicted three possible scenarios of the Delta in 20 years. GIS relates the location with its attributes and thus can provide many potential usages, such as a self-driving car, environmental monitoring etc. To me it is very crucial because biogeography usually has to be dealt with on a large scale. I am more than sure that with the compass of GIS, I would attain my goal as a successful biogeographer regardless of the thick fog. But where should I go? Pennsylvania State University, with its No. 1 rank in geography, free atmosphere, and distinguished scholars, is unsurprisingly, my first choice. I am also very happy to see that Pennsylvania State University offers both depth and flexibility to its graduate students. Thus I can design programs tailored to my interest. With the rich resources of Pennsylvania State University, and my devotion, formal background and perseverance, I am confident that I will reach my shore of success in the foreseeable future. |
2楼2007-09-05 22:16:08