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yin198716新虫 (正式写手)
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While it is suggested that endothelial hypersprouting may lead to disorganized cellular organization and ultimately vessel obstruction, this phenomenon is also reminiscent of the loss of cell polarity phenotype recently reported in endothelial β1 integrin mutants. Tumor vessel obstruction by intraluminal endothelial cells was recently reported in response to γ-secretase inhibitor treatment in both an orthotopic renal cell carcinoma and a VEGF-driven rabbit hind limb angiogenesis model. In contrast, however, a recent study demonstrated reduced microvascular occlusion and the modulation of vasoconstriction following inhibition of Dll4-Notch signaling during post-angiogenic remodeling in retinal angiogenesis. |
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cory0931
至尊木虫 (文坛精英)
巫山云
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yin198716(sltmac代发): 金币+10, 翻译EPI+1, 欢迎常来 2013-05-07 19:52:48
yin198716(sltmac代发): 金币+10, 翻译EPI+1, 欢迎常来 2013-05-07 19:52:48
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时间有点久，最近比较忙； 提示内皮细胞过度生长可能会导致细胞组织紊乱，并最终导致血管堵塞的同时；最近有关β1整合蛋白突变株的报道也暗示细胞组织紊乱后，细胞极性表型会消失。 最近报道的肿瘤血被内腔内皮细胞堵塞，是对γ分泌酶抑制子在原位肾细胞癌和兔后肢来源的VEGF引起的血管增生模型的回应。 相反的是，一项最近的研究论述说，在视网膜血管增生的血管生成与重塑之后，抑制Dll4-Notch信号，会出现微血管阻塞和血管收缩调节减少的现象。 |
2楼2013-03-30 15:20:02
cory0931
至尊木虫 (文坛精英)
巫山云
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- 专业: 临床兽医学
3楼2013-03-30 15:21:04
