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CCM1 interacts with VE-cadherin and directs adherens junction organization, distribution and association with the Par polarity complex in cultured endothelial cells and in human cerebral cavernous malformation (CCM) lesions. The emerging picture is that VEGF acts as a central driver of angiogenesis, while Notch signaling helps to coordinate the response appropriately. Conversely, targeted inactivation of EphrinB2 PDZ-dependent reverse signaling led to decreased vascularization and reduced endothelial sprouting, that is, the normalization of the tumor vasculature, in an orthotopic glioma model . |
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