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[求助]
求问orthogonal reaction详解
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| 菜鸟一个，看ＨＡ水凝胶方面的文献，一直看到有一个术语orthogonal reaction，可有有前辈指教一二，解释一下这个呀？赶紧不尽！ |
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Orthogonal reactions are based on orthogonal chemistry. Here you could more information. http://en.wikipedia.org/wiki/Bioorthogonal_chemistry ''The term bioorthogonal chemistry refers to any chemical reaction that can occur inside of living systems without interfering with native biochemical processes.The term was coined by Carolyn R. Bertozzi in 2003. Since its introduction, the concept of the bioorthogonal reaction has enabled the study of biomolecules such as glycans, proteins,and lipids in real time in living systems without cellular toxicity. A number of chemical ligation strategies have been developed that fulfill the requirements of bioorthogonality, including the 1,3-dipolar cycloaddition between azides and cyclooctynes (also termed copper-free click chemistry),between nitrones and cyclooctynes,oxime/hydrazone formation from aldehydes and ketones, the tetrazine ligation, the isonitrile-based click reaction, and most recently, the quadricyclane ligation.'' |
2楼2013-03-17 01:31:59
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