| 查看: 1070 | 回复: 9 | |||
| 【奖励】 本帖被评价6次，作者xuanzixue增加金币 4.8 个 | |||
[资源]
Avastin退出乳腺癌治疗，抗血管生成药物应该如何避免？
|
|||
|
发自PNAS的文章：Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia Antiangiogenic therapy has been thought to hold significant potential for the treatment of cancer. However, the efficacy of such treatments, especially in breast cancer patients, has been called into question, as recent clinical trials reveal only limited effectiveness of antiangiogenic agents in prolonging patient survival. New research using preclinical models further suggests that antiangiogenic agents actually increase invasive and metastatic properties of breast cancer cells. We demonstrate that by generating intratumoral hypoxia in human breast cancer xenografts, the antiangiogenic agents sunitinib andbevacizumab increase the population of cancer stemcells. In vitro studies revealed that hypoxia-driven stem/progenitor cell enrichment is primarily mediated by hypoxia-inducible factor 1α. We further show that the Akt/β-catenin cancer stem cell regulatory pathway is activated in breast cancer cells under hypoxic conditions in vitro and in sunitinib-treated mouse xenografts. These studies demonstrate that hypoxia-driven cancer stem cell stimulation limits the effectiveness of antiangiogenic agents, and suggest that to improve patient outcome, these agents might have to be combined with cancer stem cell-targeting drugs. |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : AntiangiogenicagentsincreasebreastcancerPMIDb22308314.pdf
2013-03-14 18:25:45, 1.47 M
» 收录本帖的淘帖专辑推荐
 PDT靶向相关 |
» 猜你喜欢
40+中年人失业后，还能找到好工作吗？
已经有13人回复
-
用NBS溴化时溶剂除了CCl4外还有什么
已经有6人回复
-
申请科研项目纯靠实力能成功吗？
已经有11人回复
-
极限拉扯，如何抉择
已经有15人回复
-
二审4个多月了还是Awaiting Reviewer Scores
已经有4人回复
-
OpenAI又攻克数学难题了，离AI做有机合成还有多远？
已经有13人回复
-
课题组会帮你通过考核么？
已经有7人回复
-
售一区SCI文章T0P，我:8O.551.O54,科目全,可十急
已经有9人回复
-
售SCI一区T0P文章，我:8.O55.1.O.54,科目全,可十急
已经有8人回复
-
售SCI一区文章，我:8O5.5.1.O5.4,科目全,可伽急
已经有10人回复
» 本主题相关价值贴推荐，对您同样有帮助:
- 【转】解读制药强者发展历程，挖掘强者做大做强经验
已经有12人回复
5楼2013-03-19 22:41:05
6楼2013-03-19 23:44:01
8楼2013-05-09 09:47:04
9楼2013-05-09 09:49:57
简单回复
餐盒庭钰2楼
2013-03-16 15:18
回复
五星好评 顶一下，感谢分享！
李霜楠3楼
2013-03-16 17:56
回复
五星好评 顶一下，感谢分享！
pufanlg4楼
2013-03-17 08:19
回复
五星好评 顶一下，感谢分享！
2013-05-09 09:46
回复
五星好评 顶一下，感谢分享！
inthenorth10楼
2013-09-05 11:45
回复
五星好评 顶一下，感谢分享！
200