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新书推荐：Prodrugs: Challenges and Rewards
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Prodrugs (Part 1): Challenges and Rewards By Valentino J. Stella, Ronald T. Borchardt , Michael J. Hageman , Reza Oliyai Publisher: Springer Number Of Pages: 1470 Publication Date: 2007-03-12 ISBN / ASIN: 038749782X -------------------------------------------------------------------------------- Book Description: Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the active compound. The rationale behind administering prodrugs is to optimize absorption, distribution, metabolism, and excretion of these drugs. Since first described in the 1950s, prodrugs continue to be a fertile area of research. There are a number of small pharmaceutical/biotech companies dedicated to using prodrugs for the delivery of older but problematic drugs as well as to developing broad-based prodrug technologies for application to new and future drugs. These volumes represent a comprehensive guide to prodrugs and will guide the reader through the current status of the prodrug concept and its many applications and to highlight its many successes in overcoming formulation and delivery of problematic drugs. Part I A Case for Prodrugs ................................................................................3 Valentino J. Stella Part II - Problems Addressable by Prodrugs Permeability Prodrug Approaches to Enhancing the Oral Delivery of Poorly Permeable Drugs ..............................37 Valentino J. Stella Topical Delivery Using Prodrugs ..................................................83 Kenneth B. Sloan and Scott C. Wasdo Prodrug Approaches to Ophthalmic Drug Delivery ..................125 Tomi Järvinen and Riku Niemi Solubility Oral Delivery ................................................................................158 Tycho Heimbach, David Fleisher, and Amal Kaddoumi Prodrugs and Parenteral Drug Delivery .....................................217 Jeffery Hemenway and Valentino J. Stella Metabolism Poly (ethylene glycol) Prodrugs: Altered Pharmacokinetics and Pharmacodynamics ................................283 Richard B. Greenwald and Hong Zhao Prodrugs to Reduce Presystemic Metabolism ............................339 Bruce J. Aungst and Nicole Matz Controlled Release Small Molecules ............................................................................357 Jaymin C. Shah Controlled Release – Macromolecular Prodrugs ........................379 Claus Larsen, Jesper Østergaard and Susan W. Larsen Proenzymes ...................................................................................417 Richard L. Schowen Targeting Targeting: Theoretical and Computational Models ...................429 Roger A. Rajewski and Michelle P. McIntosh Cancer—Small Molecules ............................................................447 Vincent (F.M.H.) de Groot Monoclonal Antibody Drug Conjugates for Cancer Therapy ....507 Peter D. Senter and Damon L. Meyer Antibody-Directed Enzyme Prodrug Therapy (ADEPT) ............525 Kenneth D. Bagshawe Prodrugs for Liver-Targeted Drug Delivery ................................541 Mark D. Erion Prodrug Approaches for Drug Delivery to the Brain .................573 Bradley D. Anderson Lymphatic Absorption of Orally Administered Prodrugs .........653 David M. Shackleford, Christopher J.H. Porter and William N. Charman Colonic Delivery ..........................................................................683 Fumitoshi Hirayama and Kaneto Uekama http://rapidshare.com/files/51693440/Stel_PrChaRePa1BPA.rar |
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