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| The role of EphrinB2 in this study is consistent with its recently described function as an inhibitor of VEGF signaling in endothelial tip cells upstream of Dll4-Notch.This raises the intriguing possibility that the induction of vascular changes in some organs can be manipulated by combination anti-angiogenesis therapy, while at the same time additive anti-tumor effects are achieved. |

hanches
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