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[求助]
求助翻译一段摘要，非常感谢
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Summary This study set out to evaluate, in patients with metastatic colorectal carcinoma, the efficacy and toxicity of S-1, which contains tegafur, 5-chloro-2,4-dihydroxypyridine (CDHP) and potassium oxonate, based on a biochemical modulation of 5-fluorouracil (5-FU) targeted at inhibition of dihydropyrimidine dehydrogenase (DPD). Sixty-three patients with measurable metastatic colorectal carcinoma were enrolled into the study. None of the patients had received prior chemotherapy except for adjuvant setting. S-1 was administered orally twice daily at a (R)C (R)C standard dose of 80mg m day for 28 days followed by a 14-day rest. This agent is continued until disease progression, unaccepted toxicity, or patient refusal. Twenty-two (35%) of the 62 eligible patients achieved PR with a 95% confidence interval of 25(R)C48. Five of the 10 patients with a history of adjuvant chemotherapy achieved partial remission. The median survival time was 12 months. Major adverse reactions included myelosuppressive and gastrointestinal toxicities, though their incidence of grade 3 or 4 being 13% in neutropenia and less than 10% in the others. None of the 53 patients treated as outpatients required hospitalization due to adverse reactions: These results suggest that S-1 achieves similar responses to those of infusional 5-FU plus leucovorin and shows the potential of another biochemical modulation with easily manageable toxicity. |
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hillatmsu
木虫 (小有名气)
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试试看 摘要：本研究旨在评测含有替加氟，5-氯-2,4-二羟基吡啶（CDHP）和氧嗪酸钾的S-1对于转移性结肠直肠癌病人的疗效和毒副作用。这项评测是以5 - 氟尿嘧啶（5-FU）有针对性的抑制二氢嘧啶脱氢酶（DPD）这种生化调解作用为基础的。63位检测有转移性大肠癌的病人参加了这项研究。除了辅助治疗外，这些病人之前没有接受过任何化疗。病人们首先连续28天每日两次按照（R）C（R）C标准剂量口服80mg S-1，接下来14天进行休息。这项疗程持续进行到疾病扩展、出现不可接受的毒性作用或者病人拒绝为止。62位符合条件的病人中有22个（35%）达到了95%的25（R）C48置信区间的PR比。10位有过辅助化疗历史的病人中有5位实现了部分缓解。中位生存期为12个月。主要不良反应包括骨髓抑制和胃肠道毒性，但其3或4级发病率为13%的中性粒细胞减少，和10%的胃肠道毒性。作为门诊病人的53位患者没有因为不良反应而需要住院的。这些结果表明S-1能够实现与注射5-FU加甲酰四氢叶酸类似的反应，并且显示了这是一种毒性易控的生化调解方法。 |
2楼2013-02-26 19:09:55
