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| Interestingly, although most colorectal and breast tumors showed positi ve Dll4 expression in tumor vessels, some tumors were negative. Further, at least in the case of breast cancer, the degree of Dll4 expression correlated with outcome: tumors with high Dll4 in the vasculature progressed more rapidly. More work is needed to understand the factors that regulate Dll4 expression in tumors and to extend the connection between Dll4 expression and tumor progression. |
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