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没入尘埃5

金虫 (小有名气)

[求助] miRNA的两种调控作用是不是都属于负调控 ?

miRNA的两种调控作用是不是都属于负调控 ?
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冰山来啦

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没入尘埃5: 金币+5, 有帮助 2013-03-04 14:30:07
LZ指的是哪两种调控作用啊,microRNA主要就是降解成熟的mRNA,起基因沉默作用啊
2楼2013-02-24 19:54:47
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没入尘埃5

金虫 (小有名气)

引用回帖:
2楼: Originally posted by 冰山来啦 at 2013-02-24 19:54:47
LZ指的是哪两种调控作用啊,microRNA主要就是降解成熟的mRNA,起基因沉默作用啊

microRNA的两种调控作用,一种是特异性切割靶mRNA,一种是抑制其翻译,这样看来是不是就是说这两种调控作用都是负调控,使靶基因表达量下降的
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3楼2013-02-27 08:32:19
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xiaoyu223

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没入尘埃5: 金币+10, 有帮助 2013-03-04 14:29:43
没入尘埃5: 金币+15 2013-03-11 16:55:08
都属于负调控。可参考http://en.wikipedia.org/wiki/MicroRNA
miRNAs are well conserved in eukaryotic organisms and are thought to be a vital and evolutionarily ancient component of genetic regulation.[9][10][11][12] While core components of the microRNA pathway are conserved between plants and animals, miRNA repertoires in the two kingdoms appear to have evolved independently with different modes of function.[13] Plant miRNAs usually have perfect or near-perfect pairing with their messenger RNA targets and induce gene repression through degradation of their target transcripts.[14][15] Plant miRNAs may bind their targets in both coding regions and untranslated regions.[15] In contrast, animal miRNAs typically exhibit only partial complementarity to their mRNA targets. A 'seed region' of about 6-8 nucleotides in length at the 5' end of an animal miRNA is thought to be an important determinant of target specificity.[6][16] Combinatorial regulation is a feature of miRNA regulation. A given miRNA may have multiple different mRNA targets, and a given target might similarly be targeted by multiple miRNAs.[17][18]

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4楼2013-02-27 11:02:29
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没入尘埃5

金虫 (小有名气)

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引用回帖:
4楼: Originally posted by xiaoyu223 at 2013-02-27 11:02:29
都属于负调控。可参考http://en.wikipedia.org/wiki/MicroRNA
miRNAs are well conserved in eukaryotic organisms and are thought to be a vital and evolutionarily ancient component of genetic regulation.  ...

这上面说植物的miRNA几乎全部是与靶miRNA完美配对的,那就是说植物miRNA的作用几乎都是讲解靶mRNA了,是指的从这方面讲,植物miRNA的作用都是负调控吗?
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5楼2013-02-28 11:56:56
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mlanqiang

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没入尘埃5: 金币+5, 有帮助 2013-03-04 14:29:52
没入尘埃5: 金币+5 2013-03-11 16:55:20
应该都属于负调控。
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6楼2013-02-28 12:38:58
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