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yin198716新虫 (正式写手)
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| However, antibodies targeting individual Notch receptors do not have this effect, and combined blockade of at least two receptors is necessary. Similarly, Dll4-blocking antibodies do not have gut toxicity, but have caused vascular abnormalities.Yan et al. reported that an anti-Dll4 antibody did not cause gastrointestinal toxicity, but produced marked histopathological changes in the liver of mice, rats and monkeys. |
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