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| A question of high priority is whether the approved antiangiogenic regimes are optimally used in terms of dosing, duration, and combination therapy. The role of VEGF (receptor) inhibitors in micrometast atic disease in adjuvant settings (e.g.,upon resection of the primary tumor) will require further research given the paucity of available preclinical data and suitable animal models. |

nwsuafliu
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