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| Contrary to preclinical experiments, where long-term benefit of VEGF (receptor) inhibition can be achieved, the clinical benefit in prolonging cancer patient survival with advanced disease is limited, and a fraction of patients are intrinsically refractory or acquire resistance . Recent trials using VEGF (receptor) blockers showed that the benefit, initially reported for progres-sion-free survival, was no longer detected when analyzing overall survival . |
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nwsuafliu
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