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[资源] 新药开发现状与前景《Drug Discovery and Development - Present and Future》

1.jpgDrug discovery and development process aims to make available medications that are safe and effective in improving the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, resource intensive, requiring multi-disciplinary expertise and innovative approaches. There is a growing urgency to identify and develop more effective, efficient, and expedient ways to bring safe and effective products to the market. The drug discovery and development process relies on the utilization of relevant and robust tools, methods, models, and validated biomarkers that are predictive of clinical effects in terms of diagnosis, prevention, therapy, and prognosis. There is a growing emphasis on translational research, a bidirectional bench to the bedside approach, in an effort to improve the process efficiency and the need for further innovations. The authors in the book discuss the current and evolving state of drug discovery and development.

Introductory Chapter
Overview of Current Drug Discovery and Development with an Eye towards the Future

Chapter 1
Drug Discovery and Ayurveda: Win-Win Relationship Between Contemporary and Ancient Sciences

Chapter 2
Evolutionary Biology and Drug Development

Chapter 3
Novel Oncology Drug Development Strategies in the Era of Personalised Medicine

Chapter 4
Drug Discovery into the 21st Century

Chapter 5
Genetically Engineered Mouse Models in Preclinical Anti-Cancer Drug Development

Chapter 6
Genetic Pharmacotherapy

Chapter 7
Critical Human Hepatocyte-Based In Vitro Assays for the Evaluation of Adverse Drug Effects

Chapter 8
The Use of In Vitro 3D Cell Models in Drug Development for Respiratory Diseases

Chapter 9
Chemical Biology: What is Its Role in Drug Discovery?

Chapter 10
Towards Understanding Drugs on the Molecular Level to Design Drugs of Desired Profiles

Chapter 11
De-Risking Drug Discovery Programmes Early with ADMET

Chapter 12
Novel Approach to High Throughput Screening for Activators of Transcription Factors

Chapter 13
Assessment of Cell Cycle Inhibitors by Flow Cytometry

Chapter 14
Image-Based High-Content Screening in Drug Discovery

Chapter 15
Recent Advances in Biotherapeutics Drug Discovery and Development

Chapter 16
Drug Discovery by Aptamers in Protozoan Infectious Diseases

Chapter 17
Streamlining ICH Q6B Analytical Testing of Biotherapeutics

Chapter 18
Biomarkers in Drug Development: A Useful Tool but Discrepant Results May Have a Major Impact

Chapter 19
Nanotechnology Based Targeted Drug Delivery: Current Status and Future Prospects for Drug Development

Chapter 20
Silver Nanoparticles – Universal Multifunctional Nanoparticles for Bio Sensing, Imaging for Diagnostics and Targeted Drug Delivery for Therapeutic Applications

Chapter 21
Mesenchymal Stem Cells as Vehicles for Targeted Therapies

[ 来自科研家族生物医药家族 ]

[ Last edited by Betterboy3185 on 2013-1-23 at 20:25 ]

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2013-01-23 10:28:33, 7.63 M