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yin198716гæ (ÕýʽдÊÖ)
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| Precise regulation of DLL4 expression is achieved through a TEL/CtBP repressor complex at the DLL4 promoter, which is transiently disassembled upon VEGF stimulation, allowing a temporally restricted pulse of DLL4 transcription . In line with a central function of DLL4 for vessel patterning dynamics, several other pathways, such as the Wnt/¦Â-catenin pathway, converge on the transcriptional control of DLL4. |
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- Ó¦Öú: 79 (³õÖÐÉú)
- ½ð±Ò: 1468.3
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- ºì»¨: 3
- Ìû×Ó: 417
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- ×¢²á: 2012-12-26
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yin198716: ½ð±Ò+3, ·ÒëEPI+1, ¡ïÓаïÖú 2013-01-23 14:16:11
sltmac: ½ð±Ò+2 2013-03-12 13:25:10
yin198716: ½ð±Ò+3, ·ÒëEPI+1, ¡ïÓаïÖú 2013-01-23 14:16:11
sltmac: ½ð±Ò+2 2013-03-12 13:25:10
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DLL4±í´ï׼ȷÐÔµ÷½Ú¿ÉÒÔÔÚDLL4Æô¶¯×ÓÄÚͨ¹ýTEL/CtBPÒÖÖÆ¸´ºÏÌåÀ´ÊµÏÖ. µ±´Ì¼¤Ñª¹ÜÄÚÆ¤Éú³¤Òò×Ó˲ʱ·Ö½âʱ, ¿ÉÒÔÔÝʱ¶ÔDLL4ת¼ÐγÉ×èÖ¹Âö³å. ÕâÓëѪ¹Üģʽ¶¯Á¦Ñ§¹ØÓÚDLL4ÖÐÐŦÄÜÒÔ¼°ÆäËûͨ·ÈçWnt/¦Â-Á¬»·µ°°×ͨ·¡¢DLL4µÄת¼¿ØÖƾۺÏÊÇÒ»ÖµÄ. |
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