|
|
【答案】应助回帖
★ ★ ★ ★ ★
yin198716: 金币+5, 翻译EPI+1 2013-01-17 13:47:46
1 Similar changes were observed when mice were administered an antagonistic soluble DLL4 fusion protein (the extracellular domain of DLL4 fused to human IgG1 Fc), a Notch1-specific inhibitory antibody, or the γ-secretase inhibitor dibenzazepine (DBZ) (M. Yan et al., unpublished data), indicating that these changes reflect a class effect of inhibiting DLL4-mediated Notch signalling.
当采用一种特异性Notch1抑制抗体，即拮抗性可溶DLL4融合蛋白（DLL4的胞外结构域和人IgG1 Fc蛋白融合）或γ-分泌酶抑制剂二苯并氮卓(DBZ) (M. Yan 等., 未发表数据)治疗小鼠时，也观察到类似变化，说明这些变化反映了抑制DLL4介导的Notch信号通路的类效应。
2 Because the antibody used in our study crossreacts with DLL4 proteins from multiple species, we extended our studies to rats (Sprague–Dawley) and cynomolgus monkeys (Macaca fascicularis).
我们研究中使用的抗体和来自多个物种的DLL4蛋白存在交叉反应，因此我们又把研究扩展到大白鼠 (斯泼累格•多雷，Sprague–Dawley)和食蟹猴(Macaca fascicularis)上。 |
|
回复此楼