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1 In one study, the hepatic vascular alterations observed in the Dll4 loss of function mice could be prevented by concomitant treatment with the EphrinB2 signaling inhibitors EphB4-Alb. Interestingly, the simultaneous blockade of these signaling pathways displayed additive inhibitory effects on pancreatic tumor growth and perfusion . 2This raises the intriguing possibility that the induction of vascular changes in some organs can be manipulated by combination anti-angiogenesis therapy, while at the same time additive anti-tumor effects are achieved. |
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yin198716: ½ð±Ò+5, ·ÒëEPI+1 2013-01-11 10:56:39
yin198716: ½ð±Ò+5, ·ÒëEPI+1 2013-01-11 10:56:39
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1 In one study, the hepatic vascular alterations observed in the Dll4 loss of function mice could be prevented by concomitant treatment with the EphrinB2 signaling inhibitors EphB4-Alb. Interestingly, the simultaneous blockade of these signaling pathways displayed additive inhibitory effects on pancreatic tumor growth and perfusion . Ò»ÏîÑо¿ÖУ¬ÔÚDII4¹¦ÄÜɥʧСÊóÖй۲쵽µÄ¸ÎѪ¹Ü¸Ä±ä£¬¿ÉÒÔ±»EphrinB2ÐźÅÒÖÖÆ¼ÁEphB4-AlbµÄͬ²½ÖÎÁÆ×èÖ¹¡£ÓÐȤµÄÊÇ£¬ÕâЩÐźÅͨ·µÄͬʱ×è¶Ï¶ÔÒÈÏÙÖ×ÁöÉú³¤ºÍ¹à×¢Óеþ¼ÓÒÖÖÆÐ§Ó¦¡£ 2This raises the intriguing possibility that the induction of vascular changes in some organs can be manipulated by combination anti-angiogenesis therapy, while at the same time additive anti-tumor effects are achieved. Õâ¾Í²úÉúÒ»¸öÓÕÈ˵ĿÉÄÜÐÔ£¬Ä³Ð©Æ÷¹ÙÖÐѪ¹Ü±ä»¯µÄÓÕµ¼¿ÉÒÔͨ¹ýÁªºÏ¿¹Ñª¹ÜÉú³¤ÖÎÁÆÓèÒÔµ÷¿Ø£¬Óë´Ëͬʱµþ¼Ó¿¹Ö×ÁöЧӦҲµÃÒÔʵÏÖ¡£ |

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