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1 Suppression of EphrinB2 signaling using soluble EphrinB2-Fc in a subcutaneous squamous cell carcinoma model phenocopied the effects of Dll4 blockade,in particular, reduced tumor growth accompanied by the induction of non-productive angiogenesis,suggesting that EphrinB2 acts as a downstream. 2 Conversely, targeted inactivation of EphrinB2 PDZ-dependent reverse signaling led to decreased vascularization and reduced endothelial sprouting, that is, the normalization of the tumor vasculature, in an orthotopic glioma model. |
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