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Antifertility and Enzymatic Activity
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(3)Antifertility and Enzymatic Activity About 20 Zinc enzymes are known in which Zinc is generally tetrahedrally four coordinate and bonded to hard donor atoms such as nitrogen or oxygen.The Schiff base complexes of 2-pyridinecarboxaldehyde and its derivatives have been reported to posses high super oxide dismutase activities.Recently,the interaction of DNA with complexes[Cr(Schiff base) (OH2)2]ClO4 was reported.Ternary complexes ofCu(II)containing NSO donor Schiff base showed DNA cleavage activity.In the presence of 3- mercaptopropionic acid(5mM)as a reducing agent, the complexes(40μM)show efficient DNA cleavage activity giving the order NSO-dppz>ONO-dppz> NSO-dpq>ONO dpq. |
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