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AnnF版主 (文坛精英)
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[求助]
大神们，显神通！求翻译一段英文，有BB感谢！
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In order to establish whether the overall reaction from enan-tiomer pure N -Boc-phenylalanine leads to any loss of optical purity through partial racemization in presence of base, enantiomeric excess (ee) values of L-Ia and diastereoisomeric excess (de) values based on the stereoconfi guration of amino acid amide part of fi nal product L -IIa obtained from L -N-Boc-phenylalanine were deter-mined. While Boc-deprotected product (free amine) showed an ee of 99.4%, the target compound L-IIa arising through nucleophilic addition of L- Ia on a-phosphateisothiocyanate was obtained in 98.5% de. Thus, as expected, stereochemical configuration at a-carbon atom of the acid was practically unaffected and this synthetic transformation from chiral a-amino acid could be applied to a wide range of compounds without undergoing any signi fi cant loss of optical activity. Since both L- and D -isomers of N -Boc- phenylalanine are easily accessible, it provides a useful route to obtain both the enantiomeric forms of carboxamideIa e c which are useful synthons to a variety of pharmaceuticals. The overall process for novel (L)/(D)- pseudo-peptide thioureasIIae l is convenient, high yielding and atom-economic. 11.jpg |
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【答案】应助回帖
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AnnF: 金币+5, 翻译EPI+1, ★有帮助, 辛苦了 2013-01-13 10:44:50
sltmac: 金币+10, 欢迎常来本版交流 2013-02-26 13:23:54
AnnF: 金币+5, 翻译EPI+1, ★有帮助, 辛苦了 2013-01-13 10:44:50
sltmac: 金币+10, 欢迎常来本版交流 2013-02-26 13:23:54
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In order to establish whether the overall reaction from enan-tiomer pure N -Boc-phenylalanine leads to any loss of optical purity through partial racemization in presence of base,enantiomeric excess (ee) values of L-Ia and diastereoisomeric excess (de) values based on the stereoconfiguration of amino acid amide part of final product L-IIa obtained from L-N-Boc-phenylalanine were determined. 翻译：为了确定 在碱的存在下 纯的单一对映体N-叔丁氧羰-苯丙氨酸 通过部分外消旋化 开始的全面的反应是否会引发光学纯度的损失，# （我们）对 L- IA对映体过剩值（ee）的 和 从左旋的N-叔丁氧羰-苯丙氨酸中的获得的最终产物L-IIa的部分的氨基酸酰胺的立体构型）的非对映体过剩（DE）值进行了测定。# While Boc-deprotected product (free amine) showed an ee of 99.4%, the target compound L-IIa arising through nucleophilic addition of L-Ia on a-phosphateisothiocyanate was obtained in 98.5% de. 翻译：当N—Boc保护的产物（游离胺）显示的对映体过剩值（ee）在99.4%时候，目标化合物 L-IIa的非对映体过剩值（de）在经过L-Ia亲核加成在 α-磷酸异硫氰酸盐上 可以上升到98.5%。# Thus, as expected, stereochemical configuration at a-carbon atom of the acid was practically unaffected and this synthetic transformation from chiral a-amino acid could be applied to a wide range of compounds without undergoing any significant loss of optical activity. 翻译：因此，正如所料，酸的α-碳原子的立体化学构型实际上不受影响，并且这种从手性α-氨基酸的合成转化（制备化合物）可以应用到（制备）各式各样的化合物中且不需要经过光学活性的显著丧失。# Since both L-and D-isomers of N-Boc-phenylalanine are easily accessible, it provides a useful route to obtain both the enantiomeric forms of carboxamide Ia-c which are useful synthons to a variety of pharmaceuticals. 翻译：因为L-型和D-型的N-叔丁氧羰-苯丙氨酸的同分异构体是容易得到的，这提供了一种有用的途径去获得两个对映异构体形式的甲酰胺Ia -c，其中甲酰胺Ia -c是（合成）各种药物的重要的结构单元。# The overall process for novel (L)/(D)- pseudo-peptide thioureas IIae-l is convenient, high yielding and atom-economic. 翻译：制备新型（L） /（D） - 伪肽硫脲 IIa-I 的全部过程是方便的，高产率的且具有原子经济性的。# 欢迎提出修改建议  |
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