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your2007至尊木虫 (著名写手)
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求一段英译中，万分感谢
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The experimental results demonstrate that two structurally distinct species exist in the conformational transition of apo-BLA induced by low pH. One species populates at pH 3.0 characterized as a monomeric molten globule state and the other accumulates at pH 4.0–4.5 which is a partially folded dimer. Oleic acid promotes the formation of the dimeric intermediate at pH 4.0 and 7.0, but increases the content of molten globule state remarkably at pH 3.0 compared with that in the absence of oleic acid, indicating that oleic acid at pH 3.0 plays a different role from those at pH 4.0 and 7.0. Our data provide insight into the mechanism of pH-dependent and oleic acid-dependent structural changes and oligomerization of α-lactalbumin, and will be helpful to the understanding of the apoptosis-inducing function of multimeric α-lactalbumin in which oleic acid is a necessary cofactor. |
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your2007: 金币+20, 翻译EPI+1, ★★★★★最佳答案, 谢谢 2012-12-24 11:41:36
your2007: 金币+20, 翻译EPI+1, ★★★★★最佳答案, 谢谢 2012-12-24 11:41:36
| 实验结果表明在低PH诱导的脂蛋白酶构象迁移中存在两个结构上明显不同的种类。一种在PH为3.0时以单体熔球状态出现，而另一种则在PH4.0到4.5之间以部分折叠二聚物存在。十八烯酸在PH4.0到7.0时促进二聚中间体的形成，但是在PH为3.0时，与没有十八烯酸相比，应用十八烯酸能明显增加熔球状态的容量。这表明十八烯酸在PH3.0与PH4.0到7.0之间所起的作用不同。数据表明深刻理解PH依赖与十八烯酸依赖的结构变化和α-乳清蛋白的低聚反应等的机理，对于理解十八烯酸做辅助因子的多聚α-乳清蛋白的细胞诱导凋亡功能是很有帮助的。 |
2楼2012-12-24 11:15:30