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BoaHancock金虫 (小有名气)
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CA46淋巴瘤细胞是否高表达C-myc？
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To test the above hypothesis and understand the effect of 1 on c-myc, two Burkitt ’s lymphoma cell lines with different translocation break points within the c-myc were tested. The Ramos cell line retain s the NHE III1 during trans locatio n, while the CA46 cell line has this element removed together with the P1 and P2 promoters and therefore can not form the G-qua druplex structure. 这里作者说c-myc的启动子P1和P2在基因易位中被移除，那么既然没有了启动子，c-myc应该不表达了吧？为什么别处文献多有报道CA46高表达c-myc呢？？ 求教!!! 原文名称 和地址 Inhibition of Cell Proliferation by Quindoline Derivative (SYUIQ-05) through its Preferential Interaction with c-myc Promoter G-Quadruplex http://pubs.acs.org/doi/abs/10.1021/jm200062u |
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