24小时热门版块排行榜

返回列表

当前主题已经存档。

yjlxn

至尊木虫 (著名写手)

应助: 0 (幼儿园)
金币: 15024
帖子: 2412
在线: 216小时
虫号: 118941

[资源] JASN-CKD患者代谢性骨病的发病机理及治疗策略

Metabolic Bone Disease in Chronic Kidney Disease
Kevin J. Martin and Esther A. González
Division of Nephrology, Saint Louis University, St. Louis, MO

Address correspondence to: Dr. Kevin J. Martin, Division of Nephrology, Saint Louis University Medical Center, Division of Nephrology (9-FDT), 3635 Vista Avenue, St. Louis, MO 63110l. Phone: 314-577-8765; Fax: 314-771-0784; martinkj@slu.edu

Metabolic bone disease is a common complication of chronic kidney disease (CKD) and is part of a broad spectrum of disorders of mineral metabolism that occur in this clinical setting and result in both skeletal and extraskeletal consequences. Detailed research in that past 4 decades has uncovered many of the mechanisms that are involved in the initiation and maintenance of the disturbances of bone and mineral metabolism and has been translated successfully from "bench to bedside" so that efficient therapeutic strategies now are available to control the complications of disturbed mineral metabolism. Recent emphasis is on the need to begin therapy early in the course of CKD. Central to the assessment of disturbances in bone and mineral metabolism is the ability to make an accurate assessment of the bone disease by noninvasive means. This remains somewhat problematic, and although measurements of parathyroid hormone are essential, recently recognized difficulties with these assays make it difficult to provide precise clinical practice guidelines for the various stages of CKD at the present time. Further research and progress in this area continue to evaluate the appropriate interventions to integrate therapies for both the skeletal and extraskeletal consequences with a view toward improving patient outcomes.

回复此楼

» 猜你喜欢

1楼 2007-07-21 08:21:13

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

相关版块跳转我要订阅楼主 yjlxn 的主题更新

返回列表

☆ 无星级 ★ 一星级 ★★★ 三星级 ★★★★★ 五星级

普通表情龙兔虎猫高级回复 (可上传附件)