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Abstract:Objective To investigate the influence of carbon monoxide £¨CO£© on the content of atrial natriuretic peptide £¨ANP£© in ventricular tissues of rats. Methods The left and right ventricular tissues of 12 Wistar rats were divided into control group £¨ n = 12£© and hemin group £¨n = 12, the final concentration of heroin was 10^-4 mol/L£©, respeetively, The ventfieular tissues were sucessly incubated in 37 ¡æ thermostatic waterbath with Krehs solution as supernatant for 4 hours. After incubation of the ventricular tissues, radio - immunity method was applied to determine the content of ANP in the supernatant. Results Compared with the content of ANP in the supernatant in control group, it was significantly decreased both in left [ £¨9.72 ¡À3.59£© .vs £¨52.05 ¡À 31.65£© ng/£¨g¡¤wet tissue£©, P¡´ 0,01 ] and right [ £¨5.55 ¡À 3.98£© vs £¨62.73 ¡À 41.66£© ng/£¨g¡¤ wet tissue£©, P ¡´ 0.01 ] ventricular tissues in heroin group, in control group, there was no significant difference between left and fight ventrieular tissues in the content of ANP in t he supematant; and in heroin group, the content of ANP in the supematant in left ventricular tissues was markedly lower than that in right ventricular tissues [ £¨5.55 ¡À 3.98£© vs £¨9.72 ¡À 3.95£© ng/£¨g¡¤ wet tissue£©, P¡´ 0.05 ]. Conclusions CO can inhihit the content of ANP in the supernatant both in left and right ventricu lar tissues,and the inhibitory effect of CO on the release of ANP from the supernatant may be greater in right ventricular tissues than in left ventrieular tissues.