| 查看: 962 | 回复: 4 | ||
| 本帖产生 1 个 翻译EPI ，点击这里进行查看 | ||
fuxd525木虫 (小有名气)
|
[求助]
求翻译一段摘要，个人能力有限翻译不到位
|
|
| 以吗啡啉和3,4-二氟硝基苯为原料，经取代，还原，重氮化-卤化反应合成中间体3-氟-4-吗啉基溴苯(4)；以(R)-环氧氯丙烷、氰酸钾、邻苯二甲酰亚胺钾盐为原料合成中间体(R)-5-邻苯二甲酰亚胺甲基-2-噁唑烷酮(6)。然后对(4)和(6)进行缩合、水解合成利奈唑胺。总收率由文献报道的11%左右提高至26%。该合成工艺提高了反应收率，降低了生产成本，有利于工业化生产。 |
回复此楼» 猜你喜欢
投稿精细化工
已经有6人回复
-
博士读完未来一定会好吗
已经有36人回复
-
之前让一硕士生水了7个发明专利，现在这7个获批发明专利的维护费可从哪儿支出哈？
已经有10人回复
-
博士申请都是内定的吗？
已经有9人回复
-
心脉受损
已经有8人回复
-
读博
已经有5人回复
【答案】应助回帖
★
phu_grassman: 金币-1, sorry, but you should translate it yourself. Thanks for your time. 2012-11-27 20:01:52
phu_grassman: 金币-1, sorry, but you should translate it yourself. Thanks for your time. 2012-11-27 20:01:52
| With morphine Lin and 3, 4 - two fluorine nitrobenzene as raw material via substitution, reduction, diazotization - halogenating reaction synthesis intermediates 3 - fluorine - 4 - morpholine base bromobenzene (4); To (R) - epoxy chloropropane, potassium cyanate, adjacent benzene 2 formyl imine potassium as raw materials synthesis intermediates (R) - 5 - adjacent benzene 2 formyl imine methyl - 2 - oxazole hydride ketone (6). Then (4) and (6) condensation, hydrolysis synthetic rina azole amine. The total yield is increase to 26% comparede to 11% of the reported in the literature. The synthesis process improved the yield and reduced the production cost, which be helpful for industrial production. |
2楼2012-11-26 15:18:19
3楼2012-11-26 16:17:16
fuxd525
木虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 2884.9
- 红花: 2
- 帖子: 109
- 在线: 41.5小时
- 虫号: 549266
- 注册: 2008-04-20
- 性别: GG
- 专业: 有机合成
4楼2012-11-30 09:22:34
wangzh327
木虫 (小有名气)
- 翻译EPI: 5
- 应助: 5 (幼儿园)
- 金币: 3122.3
- 红花: 1
- 帖子: 159
- 在线: 116.5小时
- 虫号: 2105902
- 注册: 2012-11-04
- 性别: GG
- 专业: 农业昆虫学
【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
220chengeng: 金币+2, 感谢应助，辛苦。 2012-12-01 21:38:12
fuxd525: 金币+25, 翻译EPI+1, ★★★很有帮助 2012-12-04 08:53:32
Carena: 金币+10, 金币代发 2013-01-12 22:07:17
220chengeng: 金币+2, 感谢应助，辛苦。 2012-12-01 21:38:12
fuxd525: 金币+25, 翻译EPI+1, ★★★很有帮助 2012-12-04 08:53:32
Carena: 金币+10, 金币代发 2013-01-12 22:07:17
|
以吗啡啉和3,4-二氟硝基苯为原料，经取代，还原，重氮化-卤化反应合成中间体3-氟-4-吗啉基溴苯(4)；以(R)-环氧氯丙烷、氰酸钾、邻苯二甲酰亚胺钾盐为原料合成中间体(R)-5-邻苯二甲酰亚胺甲基-2-噁唑烷酮(6)。然后对(4)和(6)进行缩合、水解合成利奈唑胺。总收率由文献报道的11%左右提高至26%。该合成工艺提高了反应收率，降低了生产成本，有利于工业化生产。 It can synthetize intermediates 3 - fluorine - 4 - morpholine base bromobenzene(4) through substitution, reduction and diazotization - halogenating reaction with morphine Lin and 3, 4 - two fluorine nitrobenzene；Also，It can synthetize the intermediates (R)-5-adjacent benzene 2 formyl imine methyl - 2 - oxazole hydride ketone(6)with (R)-epoxy chloropropane, potassium cyanate, adjacent benzene 2 formyl imine potassium。Then produce Nye azole amine through condensation, hydrolysis with (4) and (6)。There are literatures reported that total aromatics increased from 11% to 26%。This synthesis process can not only improve rate of reaction and reduce the cost，but also benefit industral production。 |
5楼2012-11-30 14:52:34