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专业: 生物大分子结构与功能

[求助] 关于Major Revision for Reconsideration，求帮助！！！

第一篇SCI,今天刚收到decision，给了大修，但是看专家意见里都是小问题，觉得应该小修就够了，各位看看机会大吗？谢谢了！
Thank you for submitting the above manuscript to International Journal of Biological Macromolecules.  We have now received the reviewers' reports, and regrettably I must inform you that the manuscript is not acceptable for publication in its present form, and requires major revision before it can be reconsidered for publication.

For your guidance, reviewers' comments are appended below.  I believe that the comments/suggestions made by the reviewers are self-explanatory.

If you decide to revise the work, please submit an itemized list of changes which have been made in response to the reviewer's comments/suggestions or a rebuttal of why a particular comment/suggestion was not acted upon. In order to expedite publication of the manuscript, I would appreciate receiving the revised manuscript by Dec 15, 2012.

To submit a revision, please go to http://ees.elsevier.com/ijbiomac/ and login as an Author.

On your Main Menu page is a folder entitled "Submissions Needing Revision". You will find your submission record there.

Please note that the revised manuscript will then be sent to reviewers for further consideration.

Thank you for your assistance and co-operation in the above matter. I look forward to receiving the revised manuscript.

Kind regards.

J
Editor
International Journal of Biological Macromolecules

Reviewers' comments:

Reviewer #1: The manuscript * is an original paper research on the structure features of three kinds of nanoparticles. The preparation and structure of G-NPs was novel and very interesting. PLGA-NPs and C-NPs were commonly reported, but it was rarely reported on the preparation of G-NPs. Maybe it has good potential in the controlled release delivery as the author described. The self-assembly behavior and hydrolytic erosion were important information for the application of chitosan modified PLGA NPs. So I recommend the paper for publication in International Journal of Biological Macromolecules after revision.
1)    Line 26,213 and 221.
All "mv" should be indicated as "mV".
2)    Line 115:"The excess linking reagents were removed by centrifugation and dialysis"
The expression of medium and dialysis treatment time is not clear.
3)    Line 210:" C-NPs had larger size due to the chitosan layer coating the surface of PLGA NPs. G-NPs had a mean diameter of 187.5±17.6nm, which was not significantly different with C-NPs."
Please represent the diameter of C-NPs and the statistical value.
4)    Please note the spacing mistakes and capital letters. Go over the paper and correct it.
Ex, Line 192: "The peaks at1650cm-1 and…"Please note the spacing.
"fig.3…emulsifying …" and "self-assembled… " Initial should be uppercase.
Line 300:"…(Grant No.2012DFB50140), the National Natural Science Foundation of China (Grant No. 81271727), and the Science and Technology Projects of Shandong province (Grant No. 2011GSF12124)" The spacing should be unified.
5)    In "Measurement of the hydrolytic erosion", the nanoparticles were dispersed in PBS without string? Please described clearly.

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