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[ÇóÖú] ÇëÎÊDNA Structural PropertiesÓ¦¸ÃÔõô·­Ò룿

ÌâÄ¿£ºDNA Structural Properties in the Classification of Genomic
Transcription Regulation Elements
ͻ񻣼It has been long known that DNA molecules encode information at various levels. The most basic level comprises the base
sequence itself and is primarily important for the encoding of proteins and direct base recognition by DNA-binding proteins. A more
elusive level consists of the local structural properties of the DNA molecule wherein
the DNA sequence only plays an indirect supportive
role. These properties are nevertheless an important factor in a large number of biomolecular processes and can be considered
as informative signals for the presence of a variety of genomic features. Several recent studies have unequivocally shown the benefit of
relying on such DNA properties for modeling and predicting genomic features as diverse as transcription start sites, transcription factor
binding sites, or nucleosome occupancy. This review is meant to provide an overview of the key aspects of these DNA conformational
and physicochemical properties. To illustrate their potential added value compared to relying solely on the nucleotide sequence in
genomics studies, we discuss their application in research on transcription regulation mechanisms as representative cases.
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2Â¥2012-11-16 15:37:08
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DNA Structural Properties£ºDNA½á¹¹Ìصã/ÌØÐÔ/ÐÔÖÊ
3Â¥2012-11-21 20:35:45
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DNA Structural Properties·­Òë¿ÉÄÜ£ºDNA ½á¹¹ÌØÕ÷£»DNA½á¹¹ÊôÐÔ
4Â¥2012-11-23 13:48:49
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