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【答案】应助回帖
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akuma8259357: 金币+1, 翻译EPI+1, ★有帮助 2012-11-08 22:34:07
爱与雨下: 金币+1 2012-11-09 22:07:26
有人翻译成“巴拉克”，后面半截似乎是环辛炔的意思，前面不知道，如果没有通用的中文，可以不用翻译的，不是学这个专业的，献丑了，下面是从网上找到的，但是看上去好像是机器翻译的。
Bioorthogonal chemical reactions, those that do not interact or interfere with biology, have allowed for exploration of numerous biological processes that were previously difficult to study. The reaction of azides with strained alkynes, such as cyclooctynes, readily forms a triazole product without the need for a toxic catalyst. Here we describe a biarylazacyclooctynone (BARAC) that has exceptional reaction kinetics and whose synthesis is designed to be both modular and scalable. We employed BARAC for live cell fluorescence imaging of azide-labeled glycans. The high signal-to-background ratio obtained using nanomolar concentrations of BARAC obviated the need for washing steps. Thus, BARAC is a promising reagent for in vivo imaging.
Bioorthogonal化学反应，那些不相互影响或干扰生物，允许勘探的许多生物过程，这在以前是很难学习。与应变的炔烃，如环辛炔的叠氮化物的反应，很容易形成的三唑产物而不需要一种有毒的催化剂。在这里，我们描述一个biarylazacyclooctynone（巴拉克），具有优异的反应动力学和其合成的设计是模块化和可扩展的。我们采用了巴拉克活细胞荧光成像，叠氮化物标记的多聚糖。使用纳摩尔浓度的巴拉克获得高的信号背景比避免了需要洗涤步骤。因此，巴拉克在体内成像的试剂是一种很有前途。 |
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