| 查看: 996 | 回复: 15 | |||||
| 【奖励】 本帖被评价13次，作者sfwere增加金币 10.2 个 | |||||
[资源]
Targeting the Wnt Pathway in Cancer 下载
|
|||||
|
Book Description Publication Date: January 28, 2011 | ISBN-10: 1441980229 | ISBN-13: 978-1441980229 | Edition: 1st Edition. Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway. Editorial Reviews From the Back Cover The Wnt pathway is an evolutionarily conserved signaling network that is critical for mammalian development and adult tissue maintenance, and, importantly, hyperactivated in most human cancers. Almost two decades of study has confirmed that Wnt signaling is necessary and sufficient for cancer pathogenesis in multiple in vitro and in vivo models systems, suggesting that the pathway represents an attractive therapeutic target. Recent efforts have focused on innovative strategies to antagonize Wnt signaling at various levels of the pathway – from attenuating the extracellular signaling through the Wnt receptors to modulating the catenin destruction complex to blocking catenin-mediated transcription. Many of these approaches have been largely successful in preclinical validation studies and have been met with considerable enthusiasm to move forward into clinical trials. In this book, we highlight the recent advances in our understanding of the complexity of the Wnt pathway, particularly its intricate regulation and cross-talk with other key signal transduction pathways in normal and tumor cells. As a way to comprehend the role of Wnt pathway activation in tumor initiation and progression, we discuss the importance of Wnt signaling in embryonic and tissue development and stem cell maintenance and self-renewal. The evidence for aberrant Wnt pathway activation in human solid and hematopoietic cancers, as well as a few of the genetic mouse models that mimic the Wnt pathway deregulation observed in some of these tumor types, is reviewed. Lastly, we summarize the current status of the development of Wnt pathway inhibitors, their efficacy in preclinical models and their potential as therapeutic agents for cancer. It is an exciting time in the Wnt signaling field – one that represents a key crossroad between dissecting the molecular details of the pathway and translating that work into promising targeted tumor therapies – that is likely to profoundly impact this research area for years to come. Product Details Hardcover: 252 pages Publisher: Springer; 1st Edition. edition (January 28, 2011) Language: English ISBN-10: 1441980229 ISBN-13: 978-1441980229 Product Dimensions: 6.1 x 0.7 x 9.2 inches Shipping Weight: 1.1 pounds (View shipping rates and policies) Average Customer Review: 5.0 out of 5 stars See all reviews (1 customer review) Amazon Best Sellers Rank: #3,814,675 in Books (See Top 100 in Books)  cover.jpg |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : TargetingtheWntPathwayinCancer-KathleenH.Goss.pdf
2012-10-28 23:27:03, 16.28 M
» 收录本帖的淘帖专辑推荐
 国外专业电子书 | 药物新闻 |
» 猜你喜欢
救命帖
已经有6人回复
-
存款400万可以在学校里躺平吗
已经有37人回复
-
英文综述是否需要润色及查重
已经有5人回复
-
限项规定
已经有5人回复
-
为什么nbs上溴 没有产物点出现呢
已经有9人回复
-
招博士
已经有3人回复
-
最失望的一年
已经有18人回复
» 本主题相关价值贴推荐，对您同样有帮助:
- 信号传导（附上可下载链接）
已经有4人回复
超好啊，10楼2013-01-03 16:19:13
简单回复
2012-10-29 08:04
回复
五星好评 顶一下，感谢分享！
wgx11283楼
2012-10-30 08:31
回复
五星好评 顶一下，感谢分享！
pufanlg4楼
2012-10-30 11:10
回复
五星好评 顶一下，感谢分享！
2012-11-03 14:17
回复
五星好评 顶一下，感谢分享！
2012-11-03 15:31
回复
五星好评 顶一下，感谢分享！
2012-12-26 10:19
回复
五星好评 顶一下，感谢分享！
ypwang8楼
2012-12-27 05:52
回复
三星好评 顶一下，感谢分享！
惟精惟一9楼
2012-12-30 16:34
回复
五星好评 顶一下，感谢分享！
wgx112811楼
2013-01-17 09:25
回复
顶一下，感谢分享！
一叶扁舟w12楼
2014-03-27 16:09
回复
感谢分享
zjydxy13楼
2015-10-29 12:46
回复
五星好评 顶一下，感谢分享！
yaoxuexuezi14楼
2016-10-21 14:35
回复
五星好评 顶一下，感谢分享！
wangzgsh15楼
2016-12-28 14:16
回复
五星好评 顶一下，感谢分享！
nihaoweiming16楼
2016-12-28 20:49
回复
五星好评 顶一下，感谢分享！