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fuweixing金虫 (初入文坛)
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[求助]
帮翻译一句话——临床样品量大小的确定
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Twenty-three completed patients in each treatment sequence (46 patients in total) would have 90% power to detect a difference in median total seizure frequency between treatments of 30% assuming a common standard deviation of 60% using a two sample t-test with a 5% two-sided significance level. 是否可翻译成：在5%双侧检验显著性水平条件下使用两样本t检验，设定标准偏差为60%，若每个治疗顺序组有23例受试者完成试验（共46例），则有90%的把握度来检验治疗药物组之间总癫痫发作频率中位数的差异性。 关键是30%如何翻译？求高手指点。 [ Last edited by fuweixing on 2012-10-28 at 22:19 ] |
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2楼2012-11-10 13:27:53
fuweixing
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9.7.2 Determination of sample size (第1段) Twenty-three completed patients in each treatment sequence (46 patients in total) would have 90% power to detect a difference in median total seizure frequency between treatments of 30% assuming a common standard deviation of 60% using a two sample t-test with a 5% two-sided significance level. A target sample size of sixty (30 patients in each treatment sequence) was chosen, based on the assumption that approximately 23% of the randomized patients might withdraw prior to the end of the study. Patients who withdrew from the study were not replaced. It should be noted that the sample size calculation was based on the percentage change from baseline, which was a secondary endpoint for this study, rather than the total seizure frequency which was the primary endpoint. This was due to a lack of reliable data on the primary endpoint when the sample size calculation was performed. The sample size calculation was performed using parametric assumptions. Although there would be some loss of power in performing the intended non-parametric analysis if parametric assumptions were subsequently considered reasonable, the most conservative estimate of variability available from the literature (other epilepsy sources) was used and the required sample size was, therefore, cautiously estimated9. The calculated sample size was estimated using nQuery Advisor version 4.0. |
3楼2012-11-15 08:41:57
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