| 查看: 335 | 回复: 2 | ||
[求助]
求助一篇文献，药剂学 脂质体避免抗生素耐药性的
|
|
title：Liposomal encapsulation of vancomycin improves killing of methicillin-resistant Staphylococcus aureus in a murine infection model. Abstract OBJECTIVES: Methicillin-resistant Staphylococcus aureus (MRSA) poses a major problem to public health worldwide. MRSA strains with increased resistance to vancomycin cause infections that are associated with greater morbidity and threaten the use of this once gold-standard antistaphylococcal drug. We investigated whether encapsulation of vancomycin within liposomes could improve its antistaphylococcal activity. METHODS: Two liposomal formulations of vancomycin were prepared using a rehydration-dehydration method. MICs and MBCs of the liposomal vancomycin for strains of MRSA were determined. The efficacy of one of the liposomal vancomycin formulations was also investigated in a time-kill assay in vitro and in a murine systemic infection model. RESULTS: Encapsulation in either liposome preparation decreased the vancomycin MICs and MBCs for MRSA strains by approximately 2-fold. Liposomal vancomycin increased killing of MRSA in vitro in a kinetic study. In a systemic murine infection model, treatment with a 50 mg/kg intraperitoneal injection of liposomal vancomycin improved kidney clearance of a USA300 strain by 1 log compared with an injection of 50 mg/kg of free vancomycin. CONCLUSIONS: Our findings suggest that entrapment within liposomes could improve the antistaphylococcal efficacy of vancomycin. |
回复此楼» 猜你喜欢
282求调剂
已经有11人回复
-
本科211生物医学工程085409求调剂339分
已经有8人回复
-
材料调剂
已经有3人回复
-
284求调剂
已经有13人回复
-
385分 生物学（071000）求调剂
已经有10人回复
-
材料专硕 调剂
已经有14人回复
-
求调剂
已经有5人回复
-
306分材料与化工求调剂
已经有7人回复
-
一志愿211生物学280分 求调剂
已经有3人回复
-
086000生物与医药298调剂求助
已经有9人回复
2楼2012-10-27 18:54:05
3楼2012-10-27 21:33:31
